DEVELOPMENT GRANTS IN PROSTATE CANCER

前列腺癌发展补助金

• 批准号: 2113817
• 负责人: CHARLES R MYERS
• 金额: $ 29.8万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-29 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2113817
• 关键词: biological signal transduction; cancer prevention; cell growth regulation; cellular oncology; epidermal growth factor; human subject; immunosuppression; male; metastasis; neoplasm /cancer diagnosis; neoplasm /cancer invasiveness; neoplasm /cancer therapy; oncogenes; oncology; phospholipase A2; prostate neoplasms

The University of Virginia Development Program in Prostate Cancer represents a multidisciplinary team focused on translational research aimed at reducing the incidence and mortality of prostate cancer through improved prevention, diagnosis and treatment. This application integrates tumor cell biologists and clinical investigators into a team with the ability to examine in detail the mechanisms of growth control and metastatic potential of this tumor and develop therapeutic strategies to block both phenomenon. This program is directed by Dr. Charles Myers, an authority in prostate drug discovery and includes five pilot projects, a request for support of new investigators and a planning and evaluation component. The Planning Grant includes an internal advisory committee, and a group of outstanding external consultants. Projects will examine adhesion-directed signalling, the function of the EGF receptor, the function of the ras signalling pathway and the role of phospholipase A2 and the mechanism of tumor-induced immunosuppression. These projects address aspects of tumor cell biology critical to invasiveness and growth control. The new investigator funds will be used to encourage junior and established investigators to join our team of prostate investigators.

弗吉尼亚大学前列腺癌发展计划 代表一个专注于转化研究的多学科团队 旨在通过以下方式降低前列腺癌的发病率和死亡率 改进预防、诊断和治疗。该应用程序集成了 肿瘤细胞生物学家和临床研究人员组成的团队 详细检查生长控制机制的能力 该肿瘤的转移潜力并制定治疗策略 阻止这两种现象。该计划由 Charles Myers 博士指导，他是一位 前列腺药物发现领域的权威，包括五个试点项目、一个 请求新调查人员的支持以及规划和评估 成分。规划补助金包括一个内部咨询委员会，以及 一批优秀的外部顾问。项目将审查 粘附定向信号传导、EGF 受体的功能、 ras信号通路的功能和磷脂酶A2的作用 以及肿瘤引起的免疫抑制的机制。这些项目 解决对侵袭性和生长至关重要的肿瘤细胞生物学方面的问题 控制。新的研究者资金将用于鼓励初级和 建立了研究人员加入我们的前列腺研究团队。