CHROMIUM TOXICITYAND LINK TO CERTAIN CANCERS

铬毒性及其与某些癌症的联系

• 批准号: 6118846
• 负责人: CHARLES R MYERS
• 金额: $ 0.98万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118846
• 关键词: bioengineering /biomedical engineering; biomedical resource; biotechnology; congenital disorders; plants

Preliminary studies concerning exposure of chromium to microsomes were completed at the end of 1997. In April - December 1998, systematic studies on microsomes treated with chromium were conducted once a week every week. Time course data from the ESR signal of chromium(V) was collected and compared to the UV-vis data for the reduction of chromium(VI). The rate of reduction of chromium(VI) and chromium(V) are very similar. Thus chromium is reduced in one electron steps and the existence of reactive intermediates of chromium is observed in human liver and lung microsomes. The goal of this research is to show that intracellular reductive metabolism of chromium(VI) to chromium(III), via reactive intermediates is thought to play a key role in the cytotoxicity, mutagenicity and carcinogenicity of chromium(VI) compounds. We have determined that certain aspects of rodent studies cannot be readily extrapolated to humans. This work is relevant when workers are exposed to chro mium . Exposure to chromium is associated with a wide array of toxic effects, including serious damage to internal organs and increased incidence of certain cancers.

关于铬暴露于微粒体的初步研究 已于1997年底完成。 1998年4月至12月， 对铬处理的微粒体进行了系统的研究 每周一次 来自ESR信号的时间过程数据 收集铬（V），并将其与 还原铬（VI）。 铬（VI）的还原速率和 铬（V）非常相似。 因此，铬被还原成一种 电子阶跃和铬反应中间体的存在 在人肝和肺微粒体中观察到。 这个目标 研究表明，细胞内的还原代谢， 铬（VI）到铬（III），通过反应性中间体被认为是 在细胞毒性、致突变性和 铬（VI）化合物的致癌性。 我们已经确定 啮齿动物研究的某些方面不能轻易地外推到 人类 当工人暴露于铬时，这项工作是相关的。 接触铬与一系列毒性作用有关， 包括内脏器官严重受损， 某些癌症。