CHROMIUM TOXICITYAND LINK TO CERTAIN CANCERS

铬对微粒体染毒的初步研究 已于1997年底竣工。1998年4月至12月， 对铬处理的微粒体进行了系统的研究。 每周一次。来自ESR信号的时间进程数据 收集了铬(V)，并与紫外可见光谱数据进行了比较 铬(VI)的还原。铬(VI)的还原速率和 铬(V)非常相似。因此，铬被还原为1 电子台阶与铬的活性中间体的存在 在人类的肝和肺微粒体中观察到。这样做的目的是 研究表明，细胞内的还原代谢 铬(VI)通过活性中间体转化为铬(III)被认为 在细胞毒性、致突变性和 铬(VI)化合物的致癌性。我们已经确定 啮齿动物研究的某些方面不能轻易推断到 人类。当工人接触到铬时，这项工作是相关的。 接触铬与一系列的毒性作用有关， 包括对内脏的严重损害和增加的发病率 某些癌症。

Preliminary studies concerning exposure of chromium to microsomes were completed at the end of 1997. In April - December 1998, systematic studies on microsomes treated with chromium were conducted once a week every week. Time course data from the ESR signal of chromium(V) was collected and compared to the UV-vis data for the reduction of chromium(VI). The rate of reduction of chromium(VI) and chromium(V) are very similar. Thus chromium is reduced in one electron steps and the existence of reactive intermediates of chromium is observed in human liver and lung microsomes. The goal of this research is to show that intracellular reductive metabolism of chromium(VI) to chromium(III), via reactive intermediates is thought to play a key role in the cytotoxicity, mutagenicity and carcinogenicity of chromium(VI) compounds. We have determined that certain aspects of rodent studies cannot be readily extrapolated to humans. This work is relevant when workers are exposed to chro mium . Exposure to chromium is associated with a wide array of toxic effects, including serious damage to internal organs and increased incidence of certain cancers.