CHINESE HERBS--AN ALTERNATIVE TREATMENT FOR HOT FLASHES

中药——潮热的替代疗法

• 批准号: 2284612
• 负责人: FREDI KRONENBERG
• 金额: $ 6.87万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2284612
• 关键词: alternative medicine; clinical trials; estradiol; estrone; female; flavonoids; follicle stimulating hormone; hormone regulation /control mechanism; human subject; human therapy evaluation; luteinizing hormone; medicinal plants; menopause; progesterone; sign /symptom; women's health

DESCRIPTION (adapted from applicant's abstract): Hot flashes (HFs) are the predominant complaint of menopausal women in the United States, with a prevalence of 58-93% during the first two years postmenopause. They can impact on daily functioning, particularly when they disrupt sleep, leading to fatigue during the day. Hot flashes can continue for many years postmenopausally, posing a problem of considerable magnitude for millions of women. Estrogen therapy is the most effective treatment available in Western medicine. Yet estrogen, with or without progestin, is contraindicated for some women, particularly those with breast or reproductive system cancers. Other women cannot tolerate the side effects associated with hormone therapy (HT) or are concerned whether HT might increase the risk for breast cancer. Given few medical choices, many women look for other ways to ease their passage through menopause. They experiment with "alternative" remedies. Despite this ongoing experimentation by women, and much anecdotal information about herbs, there has been no systematic examination of herbal remedies for HFs. Chinese herbs have been used for thousands of years for menopausal problems, including HFs. Some of the component herbs are known to be estrogenic in activity, but it is not known whether this might be their mechanism of action. If it is, an important concern would be whether these exogenous sources of estrogen might pose problems for those very women who take herbs because they cannot take HT. The objective of the proposed research is to examine the effect of two Chinese herbal preparations on the frequency and intensity of HFs in postmenopausal women using a double-blind, placebo-controlled crossover study design. All women will record the HFs. A subset of women will have the HFs recorded physiologically before and after the treatment phases of the study. It is proposed to measure serum estradiol, estrone, before and after active and placebo phases, and other indices of estrogenicity including the vaginal maturation index, and serum lipid levels.

描述（改编自申请人的摘要）：潮热（HF）是 美国更年期妇女的主要抱怨是 绝经后头两年的患病率为 58-93%。 他们 会影响日常功能，特别是当它们扰乱睡眠时， 导致白天疲劳。 许多人可能会持续出现潮热 绝经后数年，给女性带来了相当大的问题 数以百万计的妇女。 雌激素疗法是最有效的治疗方法 可以在西医中找到。 然而雌激素，无论有或没有孕激素， 某些女性是禁忌的，特别是那些有乳房或乳房的女性 生殖系统癌症。 其他女人无法忍受的一面 与激素治疗（HT）相关的影响或担心是否 HT 可能会增加患乳腺癌的风险。 由于医疗选择很少，许多女性寻找其他方法来缓解压力 度过更年期。 他们尝试“替代”疗法。 尽管女性正在进行这种实验，并且有很多轶事 关于草药的信息，目前还没有系统的研究 治疗心衰的草药。 中药治疗更年期已有数千年历史 问题，包括 HF。 已知一些成分草药是 雌激素活性，但尚不清楚这是否可能是它们的原因 作用机制。 如果是这样，一个重要的问题是是否 这些外源性雌激素来源可能会给那些非常健康的人带来问题。 由于不能服用激素而服用草药的女性。 拟议研究的目的是检验两种方法的效果 中药制剂对 HF 频率和强度的影响 使用双盲、安慰剂对照交叉的绝经后妇女 研究设计。 所有女性都会录制高频。 一部分女性会 记录治疗前后的 HF 生理情况 研究的阶段。 建议测量血清雌二醇， 雌酮、活性阶段和安慰剂阶段前后以及其他指标 雌激素活性，包括阴道成熟指数和血脂 水平。