课题基金 / 基金详情

CONTROL AND EXPRESSION OF TYPE 1 PILI IN E COLI

CONTROL AND EXPRESSION OF TYPE 1 PILI IN E COLI
大肠杆菌中 1 型 PILI 的控制和表达
批准号：
2061758
负责人：
PAUL Edwin ORNDORFF
金额：
$11.7万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
项目状态：
已结题
起止时间：
1985-04-01 至 2000-07-31
来源：
https://reporter.nih.gov/project-details/2061758
关键词：
Escherichia coli SDS polyacrylamide gel electrophoresis autoradiography bacterial genetics communicable disease transmission erythrocytes gene expression gene induction /repression genetic manipulation genetic recombination genetic regulation host organism interaction intermolecular interaction laboratory mouse macrophage mannose microorganism culture mutant nucleic acid sequence pilin pilus receptor binding site directed mutagenesis

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相关文献

中文摘要
翻译
大肠杆菌1型菌毛介导与多种真核细胞的黏附 研究人员合作的研究表明，他们的 在“毒力”中的主要作用是促进大肠杆菌从 动物对动物。PI的研究重点是类型1毛发的方式 与真核细胞的相互作用以及某些微小的菌毛成分如何 影响菌毛的生物发生。这样做的目的是为了在 病原菌的定植和传播，并了解更多关于 聚合型超分子结构的组装机理 将军。具体目标是1.检查分子相互作用 受体结合和2.检查菌毛组装中的分子相互作用。
英文摘要
Type 1 pili of E. coli mediate adhesion to a variety of eukaryotic cells and the investigator has collaborated in studies that show that their major role in "virulence" is to promote communicability of E. coli from animal to animal. The PI's research focuses on the way that type 1 pili interact with eucaryotic cells and how certain minor pilus components influence pilus biogenesis. The intent is to enable intervention in colonization and spread of pathogenic bacteria and to learn more about mechanisms of assembly of polymerized supramolecular structures in general. Specific aims are 1. Examine the molecular interactions in receptor binding and 2. examine molecular interactions in pilus assembly.
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