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CONTROL AND EXPRESSION OF TYPE 1 PILI IN E COLI

CONTROL AND EXPRESSION OF TYPE 1 PILI IN E COLI
大肠杆菌中 1 型 PILI 的控制和表达
批准号：
2061758
负责人：
PAUL Edwin ORNDORFF
金额：
$11.7万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
项目状态：
已结题
起止时间：
1985-04-01 至 2000-07-31
来源：
https://reporter.nih.gov/project-details/2061758
关键词：
Escherichia coli SDS polyacrylamide gel electrophoresis autoradiography bacterial genetics communicable disease transmission erythrocytes gene expression gene induction /repression genetic manipulation genetic recombination genetic regulation host organism interaction intermolecular interaction laboratory mouse macrophage mannose microorganism culture mutant nucleic acid sequence pilin pilus receptor binding site directed mutagenesis

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英文摘要
Type 1 pili of E. coli mediate adhesion to a variety of eukaryotic cells and the investigator has collaborated in studies that show that their major role in "virulence" is to promote communicability of E. coli from animal to animal. The PI's research focuses on the way that type 1 pili interact with eucaryotic cells and how certain minor pilus components influence pilus biogenesis. The intent is to enable intervention in colonization and spread of pathogenic bacteria and to learn more about mechanisms of assembly of polymerized supramolecular structures in general. Specific aims are 1. Examine the molecular interactions in receptor binding and 2. examine molecular interactions in pilus assembly.
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