Development of a novel multifunctional bioglass-based coating for the next generation of prostheses

随着人口不断老龄化，越来越多的患者需要医疗设备，如人工关节和牙科植入物，以实现日常活动。对现有植入物的改进将带来巨大的好处。特别地，迫切需要改进植入物/装置在骨中的固定而不发生感染的技术。这些将包含掺杂的纳米尺寸的生物活性玻璃，以实现与骨和抗微生物特性的强整合。拟定项目有4个关键可交付成果：1-通过最先进的制造工艺合成新型纳米材料; 2-使用这些新型材料开发最佳配方; 3-选择最佳涂层技术应用于植入物基质和4-涂层植入物原型的生物学试验。

With an ever ageing population, there are an increasing number of patients requiring medical devices, such as artificial joints and dental implants to enable everyday activity. An improvement of current implants will offer tremendous benefits. In particular, there is an urgent need for technologies to improve the fixation of implants/devices in bone without infection occurring. These will contain doped nano-sized bioactive glass to enable strong integration with bone and anti-microbial properties. The proposed project has 4 key deliverables: 1- Synthesis of novel nano- materials by state of the art manufacturing processes; 2- Development of optimum formulations with these novel materials; 3 Selection of optimum coating technique for application onto implant substrates and 4- Biological testing of coated implant prototypes.