PATHOGENESIS OF TRANSMISSIBLE MURINE COLONIC HYPERPLASIA

这项研究的目的是确定和表征 大分子，允许细菌弗氏柠檬酸杆菌生物型4280 诱导降结肠上皮细胞增殖 实验室老鼠 这种疾病称为传染性鼠结肠炎 增生，导致肠道生理学改变，类似于 人类增殖性肠道疾病 因此， 传染性小鼠结肠增生发展成结肠瘤， 潜伏期更短，剂量比未感染的小鼠低， 暴露于已知致癌物质后死亡 这项工作可能最终导致 炎症性肠病小鼠模型的发展，以及 更好地了解胃肠道 病原体、粘膜更新和癌症。

The object of this proposed research is to identify and characterize the macromolecules that allow the bacterium Citrobacter freundii biotype 4280 to induce epithelial cell proliferation in the descending colon of laboratory mice. This disease, called transmissible murine colonic hyperplasia, results in altered intestinal physiology which resembles that of human proliferative bowel disorders. Consequently, mice with transmissible murine colonic hyperplasia develop colonic neoplasia after a shorter latent period and with a lower dose than uninfected mice, following exposure to a known carcinogen. This work may ultimately lead to the development of a mouse model for inflammatory bowel disease, and a better understanding of the relationship between gastrointestinal pathogens, mucosal turnover, and cancer.