SKELETAL MUSCLE FATIGUE AND THE CONTRACTILE APPARATUS
骨骼肌疲劳和收缩装置
基本信息
- 批准号:2080945
- 负责人:
- 金额:$ 9.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1994
- 资助国家:美国
- 起止时间:1994-03-01 至 1998-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Skeletal muscle fatigue has been defined as the inability of muscle to
elicit a desired force output which it is normally capable of producing.
The development of muscle fatigue affects a number of everyday activities
including decreased exercise performance and worker productivity and is
associated with increased susceptibility to orthopedic injury and
precipitation of muscle soreness and damage. At present, the mechanisms
which cause skeletal muscle fatigue are not fully understood. [It has
recently been established that fatigue is associated with diminished
maximal Ca2+ activated force and Ca2+ sensitivity of the contractile
apparatus. Unfortunately, it is not clear if these changes are the direct
result of fatiguing activity or are secondary to the accumulation of
metabolic waste products (e.g. H+, P[i] and ADP). In addition, it is not
clear if fatigue and/or its byproducts alter the relationship between
force and Ca2+ by affecting the transitions of the cross-bridges to and
from the force generating state (cross-bridge cycling kinetics) or by
modulating cross-bridge recruitment and force generation. The experiments
described in this proposal are designed to determine l) if fatigue
directly alters maximal force production and Ca2+ sensitivity of the
contractile apparatus and 2) if fatigue- and/or metabolite-induced changes
in the relationship between force and free Ca2+ are due to altered cross-
bridge cycling kinetics or to altered cross-bridge recruitment and/or
their average force generation. This will be accomplished by examining
cross-bridge recruitment, force generation and cycling kinetics in skinned
skeletal muscle fibers taken from rested and fatigued muscles and exposed
to incubation media that is formulated to mimic "rested" and "fatigued"
intracellular environments. These parameters will be examined using
measurements of the rate constant of force redevelopment after a period of
isotonic shortening, complemented by measurements of isometric force,
ATPase activity and stiffness during isometric contraction at various
levels of free Ca2+. In general, the results of the proposed experiments
will provide much needed information regarding the mechanisms of skeletal
muscle fatigue. These findings should also lead to a better understanding
of the fatigue process and provide an experimental basis for developing
means of alleviating and avoiding muscle fatigue.]
骨骼肌疲劳被定义为肌肉不能
产生它通常能够产生的所需的力输出。
肌肉疲劳的发展会影响一些日常活动。
包括运动成绩和员工生产力的下降,以及IS
与骨科损伤的易感性增加和
肌肉酸痛和损伤的沉淀。目前,这些机制
导致骨骼肌疲劳的原因尚不完全清楚。[它有
最近证实,疲劳与衰弱有关
心肌收缩的最大钙激活力和钙敏感性
仪器。不幸的是,目前还不清楚这些变化是否直接
疲劳活动的结果或次要于
代谢废物(如H+、P[I]和ADP)。此外,它也不是
明确疲劳和/或其副产品是否会改变
力和钙离子通过影响跨桥到和的转变
从力产生状态(跨桥骑行动力学)或通过
调整跨桥招募和部队生成。这些实验
本建议中所描述的都是为了确定L)是否疲劳
直接改变细胞的最大作用力和钙敏感性
收缩装置和2)疲劳和/或代谢物引起的变化
力与游离钙离子之间的关系是由于交叉力的改变
桥梁骑行动力学或改变的跨桥招募和/或
他们的平均兵力生成。这将通过检查以下内容来实现
蒙皮动物的跨桥招募、力量产生和骑行动力学
从休息和疲劳的肌肉中取出并暴露的骨骼肌纤维
将培养基配制成模拟“休息的”和“疲劳的”
细胞内环境。将使用以下工具检查这些参数
一段时间后力再发展速率常数的测量
等张缩短法,辅之以等长力测量,
不同温度下等长收缩过程中ATPase活性和硬度的变化
游离钙离子水平。总体而言,拟议的实验结果
将提供关于骨骼机制的迫切需要的信息
肌肉疲劳。这些发现也应该有助于更好地理解
为进一步研究疲劳过程提供了实验依据。
缓解和避免肌肉疲劳的方法。]
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jay H. Williams其他文献
A Meta-Analysis of Soccer Injuries on Artificial Turf and Natural Grass
人造草坪和天然草足球损伤的荟萃分析
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Jay H. Williams;Emmanuel Akogyrem;Jeremy R Williams - 通讯作者:
Jeremy R Williams
Therapeutic effect of high speed voluntary muscle contractions on muscle soreness and muscle performance.
高速随意肌收缩对肌肉酸痛和肌肉性能的治疗作用。
- DOI:
- 发表时间:
1989 - 期刊:
- 影响因子:6.1
- 作者:
S. Hasson;W. Barnes;M. Hunter;Jay H. Williams - 通讯作者:
Jay H. Williams
Reduced Ca(2+)-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum at low pH.
低 pH 条件下,骨骼肌肌浆网中 Ca(2) 诱导的 Ca2 释放减少。
- DOI:
10.1139/y92-125 - 发表时间:
1992 - 期刊:
- 影响因子:2.1
- 作者:
Jay H. Williams;C. Ward - 通讯作者:
C. Ward
Nutrition Composition of Snacks Offered to Young Recreational Soccer Players
青少年休闲足球运动员零食的营养成分
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
M. D'Aria;Jay H. Williams;K. Hosig;M. McFerrin;E. Serrano - 通讯作者:
E. Serrano
Measurement of sarcoplasmic reticulum Ca<sup>2+</sup> ATPase activity using high-performance liquid chromatography
- DOI:
10.1016/j.ab.2007.09.020 - 发表时间:
2008-01-15 - 期刊:
- 影响因子:
- 作者:
Jay H. Williams;Stacey E. Vidt;Janet Rinehart - 通讯作者:
Janet Rinehart
Jay H. Williams的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jay H. Williams', 18)}}的其他基金
SKELETAL MUSCLE FATIGUE AND THE CONTRACTILE APPARATUS
骨骼肌疲劳和收缩装置
- 批准号:
2080947 - 财政年份:1996
- 资助金额:
$ 9.41万 - 项目类别:
SKELETAL MUSCLE FATIGUE AND THE CONTRACTILE APPARATUS
骨骼肌疲劳和收缩装置
- 批准号:
2520222 - 财政年份:1996
- 资助金额:
$ 9.41万 - 项目类别:
SKELETAL MUSCLE FATIGUE AND THE CONTRACTILE APPARATUS
骨骼肌疲劳和收缩装置
- 批准号:
2080944 - 财政年份:1994
- 资助金额:
$ 9.41万 - 项目类别:
SKELETAL MUSCLE FATIGUE AND THE CONTRACTILE APPARATUS
骨骼肌疲劳和收缩装置
- 批准号:
2376660 - 财政年份:1994
- 资助金额:
$ 9.41万 - 项目类别:
SKELETAL MUSCLE FATIGUE AND THE CONTRACTILE APPARATUS
骨骼肌疲劳和收缩装置
- 批准号:
2080946 - 财政年份:1994
- 资助金额:
$ 9.41万 - 项目类别:
相似海外基金
MOLECULAR CHARACTERIZATION OF THE SODIUM POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
- 批准号:
7461764 - 财政年份:1974
- 资助金额:
$ 9.41万 - 项目类别:
MOLECULAR CHARTERIZATION OF THE SODIUM-POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
- 批准号:
7352845 - 财政年份:1973
- 资助金额:
$ 9.41万 - 项目类别:
Molecular Characterization of the Sodium-Potassiumtransport Adenosinetriphosphatase
钠钾转运三磷酸腺苷酶的分子表征
- 批准号:
7301506 - 财政年份:1973
- 资助金额:
$ 9.41万 - 项目类别:
Continuing Grant
MOLECULAR CHARACTERIZATION OF THE SODIUM-POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
- 批准号:
7243716 - 财政年份:1972
- 资助金额:
$ 9.41万 - 项目类别:
MOLECULAR CHARACTERIZATION OF THE SODIUM-POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
- 批准号:
7138222 - 财政年份:1971
- 资助金额:
$ 9.41万 - 项目类别:
Molecular Characterization of the Sodium-Potassium Transport Adenosinetriphosphatase
钠钾转运三磷酸腺苷酶的分子表征
- 批准号:
6928993 - 财政年份:1969
- 资助金额:
$ 9.41万 - 项目类别:
Adenosinetriphosphatase Genesis in Bone Marrow Cells
骨髓细胞中腺苷三磷酸酶的发生
- 批准号:
64B2295 - 财政年份:1964
- 资助金额:
$ 9.41万 - 项目类别:
Adenosinetriphosphatase and sugar Transport Mechanism
三磷酸腺苷酶和糖转运机制
- 批准号:
6216854 - 财政年份:1962
- 资助金额:
$ 9.41万 - 项目类别:
Bone Marrow Cells and Relation to Adenosinetriphosphatase Activity
骨髓细胞及其与三磷酸腺苷酶活性的关系
- 批准号:
6216803 - 财政年份:1962
- 资助金额:
$ 9.41万 - 项目类别: