MODIFICATION OF BLOOD FLOW FOR IMPROVED TUMOR THERAPY

这项建议的目标是评估血液流动的变化是否 对血管活性物质的反应可用于预测肿瘤的变化 给药后对辐射的反应。这个 如果人们可以在此之前确定结果，那么结果将产生深远的影响 肿瘤对放射的血管活性修饰有何反应 治疗。 一种很有前途的核磁共振灌注成像(核磁共振-PI)技术将用于 测量肿瘤血流灌注分布的变化 烟酰胺和41摄氏度的微热1小时)。 肿瘤。 这项建议的具体目标是： 1)获取给药前后的核磁共振血流灌注图像 几种肿瘤模型中的烟酰胺，预计将跨越范围 对烟酰胺的血管反应。 2)延长给药前后的核磁共振-PI测量 有或没有烟酰胺的温和热度。 3)获取自发性肿瘤治疗前后的核磁共振血流灌注图像 服用烟酰胺或烟酰胺/温和的热。肿瘤 由基因工程产生的转基因小鼠将被用于 学习。 4)确定肿瘤模型中的核磁共振-PI平均值 可与同一模型中的肿瘤血流量测量结果相比较 系统使用更广泛接受的方法。核磁共振血流灌注测量 将大鼠和小鼠肿瘤模型的平均值进行比较 分别来自放射性微球和Rb摄取。 5)确定治疗后肿瘤放射反应的改变 烟酰胺/温热在自发肿瘤模型中的应用。 并在相同的动物中确定血流参数的变化 由于服用了烟酰胺/温和的高温。

The goal of this proposal is to assess whether a change in blood flow in response to a vasoactive agent can be used to predict changes in tumor response to radiation following the administration of the agent. The results will have profound implications if one could determine before therapy which tumors will respond to vasoactive modification of radiation treatment. A promising NMR perfusion imaging (NMR-PI) technique will be used to measure changes in tumor perfusion distribution in response to nicotinamide and mild heat 41 degrees C for 1 hour) in models of human tumors. The specific aims of the proposal are: 1) To obtain NMR perfusion images before and after the administration of nicotinamide in several tumor models that are expected to span the range of vascular responses to nicotinamide. 2) To extend NMR-PI measurements before and after the administration of mild heat with and without nicotinamide. 3) To obtain NMR perfusion images in spontaneous tumors before and after the administration of nicotinamide or nicotinamide/mild heat. Tumors arising from genetically engineered, transgenic mice will be used in this study. 4) To determine whether NMR-PI mean values in the tumor models employed compare favorably with measurements of tumor blood flow in the same model systems using more widely-accepted methods. NMR perfusion measurements in rat and mouse tumor models will be compared with the average value from radioactive microspheres and rubidium uptake, respectively. 5) To determine the modification in tumor radiation response following the administration of nicotinamide/mild heat in spontaneous tumor models. And to determine in the same animals the change in a blood flow parameter due to the administration of nicotinamide/mild heat.