TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
批准号:
2092102
负责人:
MICHAEL A RODGERS
金额:
$17.74万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-09-01 至 1998-07-31
关键词:
analog chemical association chemical structure chemical synthesis combination cancer therapy disease /disorder model infrared radiation laboratory mouse laser therapy low density lipoprotein melanins melanoma neoplasm /cancer pharmacology neoplasm /cancer photoradiation therapy neoplasm /cancer thermotherapy nonhuman therapy evaluation pharmacokinetics photobiology photosensitizing agents phthalocyanin radiation dosage tissue /cell culture
中文摘要
在继续这项合作中要检验的假设
项目是,光疗是适用于治疗高度
色素性肿瘤,如皮肤恶性黑色素瘤(CMM)。这
假设将通过(a)确定
在色素性肿瘤中的光动力疗法(PDT),(B)确定是否
PDT可以应用于已经被高浓度的光化学漂白剂预漂白的黑色素瘤,
峰值功率光,(c)建立光热的有用性
PTT疗法(PTT)治疗此类肿瘤。该假设将通过以下方式进行检验:
合成了一系列近红外光吸收光敏剂,
用于PDT和HT的化合物并测定它们的有效性。化合物
将合成的是金属中心的萘酞菁,
各种轴向和外周取代基,其将提供溶解性,
肿瘤保留修饰。
光物理测量将解决有关自然的问题,
寿命和低电子态的失活模式,
有助于表征化合物在细胞中起作用的能力。
PDT和HT模式。药代动力学研究将讨论
小鼠系统内PDT和HT的潜在致敏剂(B16恶性
黑色素瘤);和光疗测试将确定的有效性,
各种致敏剂,并允许设计用于临床的方案
评价
英文摘要
The hypothesis to be tested in the continuation of this collaborative
project is that phototherapy is applicable to the treatment of highly
pigmented tumors such as cutaneous malignant melanoma (CMM). This
hypothesis is to be evaluated by (a) establishing the limits of
photodynamic therapy (PDT) in pigmented tumors, (b)establishing whether
PDT can be applied to melanotic tumors that have been prebleached by high-
peak-power light, and (c) establishing the usefulness of photothermal
therapy (PTT) to such tumors. The hypothesis will be tested by
synthesizing a series of near-IR-light absorbing photosensitizing
compounds for PDT and for HT and assaying their effectiveness. Compounds
to be synthesized will be metallo-centered naphthalocyanines having
various axial and peripheral substituents that will provide solubility and
tumor retention modifications.
Photophysical measurements will address questions about the nature,
lifetime, and deactivation modes of low-lying electronic states and will
assist in characterizing the capabilities of the compounds to act in the
PDT and HT modes. Pharmacokinetic studies will address the distribution of
potential sensitizers for PDT and HT within murine systems (B16 malignant
melanoma); and phototherapeutic tests will determine the effectiveness of
the various sensitizers and allow the design of protocols for clinical
evaluation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Photothermal Sensitization of Biological Systems
-
批准号:6321485
-
项目类别:
-
资助金额:$27.63万
-
财政年份:2001
-
负责人:MICHAEL A RODGERS
-
依托单位:
Photothermal Sensitization of Biological Systems
-
批准号:6515037
-
项目类别:
-
资助金额:$24.6万
-
财政年份:2001
-
负责人:MICHAEL A RODGERS
-
依托单位:
Photothermal Sensitization of Biological Systems
-
批准号:6634041
-
项目类别:
-
资助金额:$25.27万
-
财政年份:2001
-
负责人:MICHAEL A RODGERS
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3523600
-
项目类别:
-
资助金额:$0.5万
-
财政年份:1991
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY - NEW PHOTODYNAMIC SENSITIZERS
-
批准号:3189514
-
项目类别:
-
资助金额:$13.56万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
-
批准号:3189508
-
项目类别:
-
资助金额:$10.66万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
-
批准号:2092101
-
项目类别:
-
资助金额:$13.89万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
-
批准号:2092103
-
项目类别:
-
资助金额:$16.51万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
-
批准号:3189513
-
项目类别:
-
资助金额:$10.34万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY - NEW PHOTODYNAMIC SENSITIZERS
-
批准号:3189510
-
项目类别:
-
资助金额:$16.03万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
-
批准号:3189512
-
项目类别:
-
资助金额:$10.16万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS
-
批准号:2458056
-
项目类别:
-
资助金额:$17.5万
-
财政年份:1988
-
负责人:MICHAEL A RODGERS
-
依托单位:
SINGLET OXYGEN IN BIOLOGICAL SYSTEMS
-
批准号:2174225
-
项目类别:
-
资助金额:$15.21万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
SINGLET OXYGEN IN BIOLOGICAL SYSTEMS
-
批准号:3272131
-
项目类别:
-
资助金额:$19.94万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
SINGLET OXYGEN IN BIOLOGICAL SYSTEMS
-
批准号:3272137
-
项目类别:
-
资助金额:$12.52万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
ELECTRON TRANSFER IN MICRO-HETEROGENEOUS MEDIA
-
批准号:3279741
-
项目类别:
-
资助金额:$10.02万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
ELECTRON TRANSFER IN MICRO-HETEROGENEOUS MEDIA
-
批准号:3279742
-
项目类别:
-
资助金额:$9.88万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
SINGLET OXYGEN IN BIOLOGICAL SYSTEMS
-
批准号:2444473
-
项目类别:
-
资助金额:$11.91万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
SINGLET OXYGEN IN BIOLOGICAL SYSTEMS
-
批准号:3272139
-
项目类别:
-
资助金额:$14.26万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
SINGLET OXYGEN IN BIOLOGICAL SYSTEMS
-
批准号:2174228
-
项目类别:
-
资助金额:$13.22万
-
财政年份:1987
-
负责人:MICHAEL A RODGERS
-
依托单位:
海外基金