TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS

肿瘤光疗--新型光动力增敏剂

• 批准号: 3189513
• 负责人: MICHAEL A RODGERS
• 金额: $ 10.34万
• 依托单位: BOWLING GREEN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3189513
• 关键词: cellular oncology; disease /disorder model; drug screening /evaluation; heme; laboratory mouse; liposomes; naphthalenes; nonvisual photosensitivity; phototherapy; porphyrins; singlet oxygen

This is a new application that concerns the development and optimization of a new generation of photosensitizers for photodynamic therapy (PDT) of tumors and other health conditions. The molecules selected for study are, chemically, of the naphthalocyanine (NC) family. NC's are based on a tetrapyrroloid macrocycle. Preliminary photophysicial studies have shown one representative of this class as having light absorption and photochemical characteristics that are required for improving upon the performance of the photosensitizer (hematoporphyrin derivative) currently undergoing chemical trials. The program involves a synthetic facet in which NC's of different structure, optical absorption and solubility properties will be synthesized and characterized (Dr. M. E. Kenny will collaborate here). There is a facet that requires the use of time- resolved kinetic methods to quantify the photophysical properties of the designated systems in a variety of environments. The third facet involveds photobiological studies at the cellular and animal tumor level (these last in collaboration with Dr. G. Jori). The three laboratories where this research will proceed are all excellently equipped with the requisite facilities.

这是一个新的应用程序，涉及的发展和 优化新一代光敏剂， 光动力疗法（PDT）的肿瘤和其他健康 条件 选择用于研究的分子在化学上是 naphthalene（NC）家族。 NC基于 四吡咯大环 初步学术研究 已经展示了这类的一个代表， 所需的吸收和光化学特性 为了改善光敏剂的性能， （血卟啉衍生物）目前正在进行化学 审判 该计划涉及一个合成方面，其中NC的 不同的结构、光学吸收和溶解性 将被合成和表征（M。E.肯尼会 合作）。 有一个方面需要利用时间- 分解动力学方法来量化物理性质 在各种环境中的指定系统。 第三 涉及细胞和动物的光生物学研究 肿瘤水平（最后与G. Jori）。 的 进行这项研究的三个实验室都是 配备了必要的设施。