Purification of Adeno-Associated Virus (AAV) by continuous Chromatography

该项目旨在通过改进纯化工艺和采用连续色谱法，提高用于人类基因治疗研究的腺相关病毒（AAV）载体的产量。该项目旨在开发具有更高产量和稳健性的纯化工艺，这些工艺可以很容易地扩展到市场需求所需的工艺，而商品成本低于目前针对这些病媒所实现的成本，从而满足增加这些药物供应和成本的关键需求。

The project aims to increase yields of Adeno-Associated Viral (AAV) vectors for human gene therapy studies through the improved purification processes and through the adoption of continuous chromatography approaches. The project aims to develop purification processes with improved yields and robustness that can be readily scaled to those required for in-market requirements at a reduced cost of goods than is currently being achieved for these vectors, addressing the critical needs to increase the supply and costs of these medicines.