PHYSIOLOGICAL FACTORS IN HYPERTHERMIA

血液循环在热诱导的组织损伤中起着重要作用， 加热期间的组织温度和组织内环境因素， 影响热损伤，如pH值和营养供应， 与血流有关。 血液流动本身会因热量而显著改变， 因此血液流动如何被热改变直接决定了 组织会被热损坏。 热引起的皮肤和肌肉中血流的变化已经被证实是 有据可查 相比之下，人们对热的影响知之甚少。 其他正常组织中的血流，特别是内部器官。 本建议的第一个目的是阐明热的影响 对大鼠主要内脏器官的血液流动的影响。 最近的研究表明，血液循环系统 使第二次和随后的加热不那么有效 比第一次加热更能改变血流。 间接证据 表明这种血管适应性至少部分是由于 血管壁中血管耐热性的发展。 第二 本建议的目的是获得深入了解动力学和规模 正常组织和R3230 Ac的血管耐热性 大鼠腺癌。 已经提出肿瘤血流可能被选择性地减少， 并因此通过使用血管活性物质在高热中被优先加热 化合物. 第三个目的是继续我们对血液变化的研究 在不同的正常组织和R3230 Ac肿瘤生长在不同的 通过各种血管活性剂如肼苯哒嗪，硝普钠， 黄酮乙酸（FAA）和白细胞介素-1（IL-1）。 然后我们将 探讨热药合用对正常人血流量的影响 组织和肿瘤。 使用动物模型的拟议研究将提供重要的 有效利用热疗控制人体 癌

Blood circulation plays a cardinal role in heat-induced tissue damage since tissue temperature during heating and intratissue environment factors which affect thermal damage, such as pH and nutritional supply, are closely related to blood flow. The blood flow itself is markedly altered by heat, and thus how the blood flow is changed by heat directly dictates how the tissues are damaged by heat. The heat-induced changes in blood flow in the skin and muscle have been well documented. In contrast, little is known about the effects of heat on the blood flow in other normal tissues, particularly in internal organs. The first aim of the present proposal is to elucidate the effects of heat on the blood flow in major internal organs of rats. It has recently been demonstrated that the blood circulatory system adapts to heat-stress so that second and subsequent heatings are less effective than the first heating in changing the blood flow. Circumstantial evidence suggests that such vascular adaptation is due, at least in part, to development of vascular thermotolerance in the vessel walls. The second aim of this proposal is to obtain insight into the kinetics and magnitude of vascular thermotolerance in the normal tissues and R3230 Ac adenocarcinoma of rats. It has been suggested that tumor blood flow might be selectively reduced, and thus be preferentially heated in hyperthermia by using vasoactive compounds. The third aim is to continue our study on the change sin blood flow in various normal tissues and in R3230 Ac tumors grown in different sites by various vasoactive agents such as hydralazine, nitroprusside, flavone acetic acid (FAA) and Interleukin-1 (IL-1). We will then investigate the combined effects of heat and drugs on blood flow in normal tissues and tumors. The proposed studies using animal models would provide important information for the effective use of hyperthermia in the control of human cancer.