PHYSIOLOGICAL FACTORS IN HYPERTHERMIA

血液循环在热致组织损伤中起着主要作用，因为 加热过程中的组织温度和血管内环境因素 影响热损伤的因素，如酸碱度和营养供应，都是密切相关的 与血液流动有关。血液流动本身会因受热而发生显著变化， 因此，血液流动如何因热量而改变，直接决定了 组织会因受热而受损。 热引起的皮肤和肌肉中血液流动的变化 有据可查。相比之下，人们对高温对人体健康的影响知之甚少 血液在其他正常组织中的血液流动，特别是在内部器官中。 本提案的第一个目的是阐明高温的影响。 对大鼠主要脏器血流的影响。 最近的研究表明，血液循环系统能够适应 热应激，使第二次和随后的加热效果较差 比第一次加热更能改变血液流动。间接证据 这表明，这种血管适应至少部分是由于 血管壁中血管耐热性的发展。第二 这一建议的目的是为了深入了解动力学和幅度 正常组织和R3230Ac血管耐热性的研究 大鼠腺癌。 有人建议，肿瘤血流量可能会选择性地减少， 从而通过使用血管活性物质在热疗中优先加热 化合物。第三个目标是继续我们对血液变化的研究。 不同正常组织和不同生长方式的R3230Ac肿瘤中的血流 不同的血管活性物质，如肼，硝普钠， 黄酮乙酸(FAA)和白介素1(IL-1)。到时候我们会的 热和药物联合作用对正常人血流的影响 组织和肿瘤。 拟议的使用动物模型的研究将提供重要的 关于有效利用热疗控制人体健康的信息 癌症。

Blood circulation plays a cardinal role in heat-induced tissue damage since tissue temperature during heating and intratissue environment factors which affect thermal damage, such as pH and nutritional supply, are closely related to blood flow. The blood flow itself is markedly altered by heat, and thus how the blood flow is changed by heat directly dictates how the tissues are damaged by heat. The heat-induced changes in blood flow in the skin and muscle have been well documented. In contrast, little is known about the effects of heat on the blood flow in other normal tissues, particularly in internal organs. The first aim of the present proposal is to elucidate the effects of heat on the blood flow in major internal organs of rats. It has recently been demonstrated that the blood circulatory system adapts to heat-stress so that second and subsequent heatings are less effective than the first heating in changing the blood flow. Circumstantial evidence suggests that such vascular adaptation is due, at least in part, to development of vascular thermotolerance in the vessel walls. The second aim of this proposal is to obtain insight into the kinetics and magnitude of vascular thermotolerance in the normal tissues and R3230 Ac adenocarcinoma of rats. It has been suggested that tumor blood flow might be selectively reduced, and thus be preferentially heated in hyperthermia by using vasoactive compounds. The third aim is to continue our study on the change sin blood flow in various normal tissues and in R3230 Ac tumors grown in different sites by various vasoactive agents such as hydralazine, nitroprusside, flavone acetic acid (FAA) and Interleukin-1 (IL-1). We will then investigate the combined effects of heat and drugs on blood flow in normal tissues and tumors. The proposed studies using animal models would provide important information for the effective use of hyperthermia in the control of human cancer.