PHYSIOLOGICAL FACTORS IN HYPERTHERMIA

血液循环在热引起的组织损伤中起着重要作用，因为 加热过程中的组织温度和组织内环境因素 影响热损伤的因素，例如 pH 值和营养供应，与 与血流有关。 血液流动本身会因热量而显着改变， 因此，热量如何改变血流直接决定了 组织因热而受损。 热引起的皮肤和肌肉血流变化 有据可查。 相比之下，人们对热量的影响知之甚少。 其他正常组织中的血流，特别是内脏器官中的血流。 本提案的首要目标是阐明热的影响 对大鼠主要内脏器官血流的影响。 最近的研究表明，血液循环系统可以适应 热应激，使得第二次和后续加热的效果较差 比第一次加热改变血流的效果要好。 间接证据 表明这种血管适应至少部分归因于 血管壁的血管耐热性的发展。 第二个 该提案的目的是深入了解动力学和大小 正常组织和 R3230 Ac 中血管耐热性的影响 大鼠腺癌。 有人提出，肿瘤血流量可能会选择性减少， 因此，优先使用血管活性物质进行高热加热 化合物。 第三个目标是继续我们对罪血变化的研究 在各种正常组织和在不同环境中生长的 R3230 Ac 肿瘤中流动 各种血管活性药物如肼屈嗪、硝普钠、 黄酮乙酸 (FAA) 和白介素-1 (IL-1)。 我们随后将 研究热和药物对正常人血流的综合影响 组织和肿瘤。 拟议的使用动物模型的研究将提供重要的 有关有效利用热疗控制人类健康的信息 癌症。

Blood circulation plays a cardinal role in heat-induced tissue damage since tissue temperature during heating and intratissue environment factors which affect thermal damage, such as pH and nutritional supply, are closely related to blood flow. The blood flow itself is markedly altered by heat, and thus how the blood flow is changed by heat directly dictates how the tissues are damaged by heat. The heat-induced changes in blood flow in the skin and muscle have been well documented. In contrast, little is known about the effects of heat on the blood flow in other normal tissues, particularly in internal organs. The first aim of the present proposal is to elucidate the effects of heat on the blood flow in major internal organs of rats. It has recently been demonstrated that the blood circulatory system adapts to heat-stress so that second and subsequent heatings are less effective than the first heating in changing the blood flow. Circumstantial evidence suggests that such vascular adaptation is due, at least in part, to development of vascular thermotolerance in the vessel walls. The second aim of this proposal is to obtain insight into the kinetics and magnitude of vascular thermotolerance in the normal tissues and R3230 Ac adenocarcinoma of rats. It has been suggested that tumor blood flow might be selectively reduced, and thus be preferentially heated in hyperthermia by using vasoactive compounds. The third aim is to continue our study on the change sin blood flow in various normal tissues and in R3230 Ac tumors grown in different sites by various vasoactive agents such as hydralazine, nitroprusside, flavone acetic acid (FAA) and Interleukin-1 (IL-1). We will then investigate the combined effects of heat and drugs on blood flow in normal tissues and tumors. The proposed studies using animal models would provide important information for the effective use of hyperthermia in the control of human cancer.