PHYSIOLOGICAL FACTORS IN HYPERTHERMIA

热疗联合放射治疗或 化疗正在成为一种既定的治疗方式 癌症的治疗。尽管恶性细胞不是 肿瘤细胞必然比正常细胞对热更敏感 通常比正常组织更容易受热。它是 认为血管结构的内在差异是因为 以及血管系统的热反应和相关 肿瘤和正常组织中的生理代谢因子 是体温过高对患者产生如此有利作用的主要原因 肿瘤。具体地说，肿瘤中的体温往往会上升 在加热过程中高于邻近正常组织，由于 由于血液流动迟缓而散热效率低下。 肿瘤相对于正常组织中的肿瘤。众所周知， 哺乳动物细胞的热敏性是深刻的 因酸性和不良的营养条件而增强。有趣的是， 肿瘤内环境是酸性的，营养匮乏。 这种情况在加热的肿瘤中可能会进一步增强。 由于血管功能和相关的生理生化 影响热疗效果的因素。从长远来看 本研究的目的是为了进一步了解血液的作用 高温处理中的流动及相关微环境 癌症的威胁。本申请的具体目的是阐明 正常内脏器官受热引起的血管变化。 受热引起的皮肤组织血液流动的变化 已被广泛研究，但热对血液流动的影响 在其他正常组织中，包括体腔内的器官， 几乎是未知的。这可能归因于这样一个事实，即 目前还没有合适的设备来加热深层内脏 可用。我们最近买了一台电容式加热装置 能够加热实验动物的深层内脏。 我们建议研究热对血液流动的影响和 还确定了血管损伤的阈值热剂量 大鼠的各种内脏。血流量将被测量 使用放射性微球方法，这种方法长期以来一直 在我们的实验室建立。我们坚信这一消息 在这项研究中得到的将提供一个理论基础， 有效应用热疗治疗人体深部肿瘤 可以是有计划的。

Hyperthermia used in combination with radiotherapy or chemotherapy is becoming an established modality for the treatment of cancer. Although malignant cells are not necessarily more heat-sensitive than normal cells, tumors are generally more vulnerable to heat than are normal tissues. It is believed that the intrinsic difference in the vascular structure as well as the thermal response of vasculature and related physiological and metabolic factors in tumors and normal tissues is the main cause of such preferential effect of hyperthermia on tumors. Specifically, the temperature in tumors tends to rise higher than that in adjacent normal tissues during heating, owing to the inefficient heat dissipation by the sluggish blood flow in the tumors relative to that in the normal tissues. It has been known that the thermosensitivity of mammalian cells is profoundly enhanced by acidic and poor nutritional conditions. Interestingly, the intratumor environment is acidic and nutritionally deprived. This condition is further enhanced in the heated tumor probably due to vascular function and related physiological and biochemical factors for the effective use of hyperthermia. The longterm objective of this sutdy is to further understand the role of blood flow and related microenvironment in the hyperthermic treatment of cancer. The specific aim of this application is to elucidate the heatinduced vascular changes in normal internal organs. The heatedinduced change in blood flow in cutaneous tissue has been extensively studied, but the effect of heat on the blood flow in other normal tissues, including the organs in the body cavity, is virtually unknown. This may be attributed to the fact that a suitable device to heat the deep internal organs has not been available. We recently acquired a capacitive heating device capable of heating deep internal organs of experimental animals. We propose to investigate the effect of heat on the blood flow and also determine the threshold thermal dose for vascular damage in various internal organs of rats. The blood flow will be measured with the radioactive microsphere method, which has long been established in our laboratory. We strongly believe the information obtained in this study will provide a rationale basis on which an effective use of hyperthermia to treat deepseated human tumors can be planned.