GROWTH & DIFFERENTIATION OF IMMATURE T CELLS & THYMOMAS

这个项目有两个潜在的相关目标。第一个目标是 确定刺激细胞和分子的相互作用 发育不成熟的胸腺细胞。第二个目标是调查 这些相互作用如何参与到 恶性胸腺肿瘤。这些研究将提供对 免疫系统的发展以及这个过程是如何 在恶性中变得无序。实验设计将 开发一种独特的体外模型来定义什么细胞相互作用 和信号刺激未成熟肿瘤增殖和 差异化。然后，这些研究将扩展到分析 肿瘤在体内的生长要求。其他实验将会 将这些研究扩展到分析正常的发展 胸腺细胞。

This project has two potentially related goals. The first goal is to identify the cellular and molecular interactions that stimulate immature thymocytes to develop. The second goal is to investigate how these interactions may be involved in the development of malignant thymic tumors. These studies will provide insight into the development of the immune system and into how this process becomes disordered in malignancy. The experimental design will develop a unique in vitro model to define what cell interactions and signals stimulate immature tumors to proliferate and differentiate. These studies will then be extended to analyze the growth requirements of tumors in vivo. Other experiments will extend these studies to analyze the development of normal thymocytes.