A novel Rhamnosidase: immobilised for repeated biocatalysis use to produce high value chemicals

“生物启发的过程将对21世纪全球社会的挑战产生重大影响，包括与环境可持续性有关的挑战。在工业过程中使用生物催化剂有望促进可再生资源的化学品、材料和燃料的可持续生产。该提案的范围是鼓励学术研究及其成果转化为可持续生产商业高价值材料的新型工业可用平台技术。鼠李糖脂（RL）是由某些微生物产生的糖脂家族的生物表面活性剂（Kiran et al. 2016\*），这可以满足消费者对日常产品中环保、可持续生产的成分日益增长的需求。RL是由含有一个（单RL）或两个（二RL）鼠李糖分子的脂质和糖部分组成的化合物。Di-RL、Mono-RL和鼠李糖都具有更广泛的商业应用潜力（鼠李糖在调味品/食品工业和护肤品中，RL在护肤品、织物/表面清洁和制药中）。该项目将解决RL物种生物催化转化过程中的关键挑战，因此将成为向市场提供可扩展的多样化产品的关键推动因素。Kiran等人（2016）鼠李糖脂生物表面活性剂：未开发海洋资源的演变影响，应用和未来前景。Crit Rev Biotechnol.，36（3）：399-415”

"Bio-inspired processes will have a major impact on the challenges of the global society in 21st century, including those associated with environmental sustainability. The employment of biocatalysts in industrial processes is expected to boost a sustainable production of chemicals, materials and fuels from renewable resources. The scope of this proposal is to encourage and translate academic research and its outcome into a novel industrially usable platform technology for the sustainable production of commercial high value materials.Rhamnolipids (RL) are biosurfactants from the glycolipid family produced by certain microorganisms (Kiran et al. 2016\*) that could address the growing consumer demand for environmentally friendly, sustainably produced ingredients in everyday products. RL are chemical compounds composed of lipid and sugar moieties containing one (mono-RL) or two (di-RL) molecules of Rhamnose. Di-RL, Mono-RL and Rhamnose all have potential for broader commercial applications (Rhamnose in the flavour/food industry & Skincare, RLs in Skincare, Fabric/Surface Cleaning and Pharmaceuticals). This project will address key challenges in the process of the biocatalytic conversion of RL species, and will therefore be a key enabler for a scalable supply of diverse products to the market.\* Kiran at al. (2016) Rhamnolipids Biosurfactants: evolutionary implications, applications and future prospects from untapped marine resource. Crit Rev Biotechnol., 36(3): 399-415"