GROWTH & DIFFERENTIATION OF IMMATURE T CELLS & THYMOMAS

生长

• 批准号: 2096448
• 负责人: KENNETH L ROCK
• 金额: $ 21.78万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1997-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2096448
• 关键词: T cell receptor; T lymphocyte; antireceptor antibody; biological signal transduction; cell cell interaction; cell differentiation; cell growth regulation; extracellular matrix; flow cytometry; hamsters; immunofluorescence technique; laboratory mouse; monoclonal antibody; neoplastic growth; thymus; thymus neoplasms; tissue /cell culture

This project has two potentially related goals. The first goal is to identify the cellular and molecular interactions that stimulate immature thymocytes to develop. The second goal is to investigate how these interactions may be involved in the development of malignant thymic tumors. These studies will provide insight into the development of the immune system and into how this process becomes disordered in malignancy. The experimental design will develop a unique in vitro model to define what cell interactions and signals stimulate immature tumors to proliferate and differentiate. These studies will then be extended to analyze the growth requirements of tumors in vivo. Other experiments will extend these studies to analyze the development of normal thymocytes.

该项目有两个潜在的相关目标。 第一个目标是 以确定细胞和分子之间的相互作用， 未成熟的胸腺细胞发育。 第二个目标是调查 这些相互作用如何参与发展 恶性胸腺肿瘤 这些研究将提供深入了解 免疫系统的发展以及这个过程 在恶性肿瘤中变得紊乱。 实验设计将 开发一个独特的体外模型来定义细胞之间的相互作用 信号刺激未成熟的肿瘤增殖， 区分。 这些研究将扩展到分析 肿瘤在体内的生长需求。 其他实验将 扩展这些研究，以分析正常的发展， 胸腺细胞