BIOLOGY OF THE PROLIFERATING CELL NUCLEAR ANTIGEN

增殖细胞核抗原的生物学

• 批准号: 2095350
• 负责人: RENATO Luigi BASERGA
• 金额: $ 15万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-01 至 1995-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2095350
• 关键词: DNA binding protein; DNA replication; cell cycle proteins; cell growth regulation; genetic promoter element; genetic regulatory element; genetic transcription; messenger RNA; nucleic acid sequence; transcription factor

The Proliferating Cell Nuclear Antigen (PCNA) is the co-factor of DNA polymerase delta, a Key enzyme in cellular DNA synthesis. Is is required for DNA replication and cell cycle progression. Because of the important role that PCNA plays in proliferating cells and because of some unusual aspects in the structure and function of its gene, we propose to investigate the growth-regulation of the PCNA gene, how growth factors affect it and which trans-acting factors interact with its regulatory elements. This project's goal is a better understanding of the factors that regulate cell cycle progression at the G1/S boundary.

增殖细胞核抗原（PCNA）是DNA的辅助因子