A Role of the IGF-1 Receptor In Aging

IGF-1 受体在衰老中的作用

• 批准号: 6941593
• 负责人: RENATO Luigi BASERGA
• 金额: $ 31.26万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941593
• 关键词: binding proteins; biological signal transduction; cell differentiation; cell growth regulation; cell senescence; growth factor receptors; guanine nucleotide binding protein; insulinlike growth factor; longevity; oncoproteins; tissue /cell culture; transcription factor

DESCRIPTION (provided by applicant): The type 1 insulin-like growth factor receptor (IGF-1R) is known to play an important role in aging. My laboratory has been interested for some time in the biology of the IGF-1R and its signaling. Recently, we have found that the IGF-1R, directly or indirectly, modulates the expression and/or the activity of three proteins, all of which have been implicated in aging, either in vivo or in vitro. These three proteins are: 1) the Id proteins, that are transcriptional factors involved in the control of cell proliferation and cell differentiation. The Idl protein has been shown to delay cellular senescence. 2) the Ras oncoprotein, which, in certain circumstances, induces a senescent-like state in cells in culture. 3) the p66 isoform of the Shc proteins, that plays a role in the longevity of mice. The involvement of the IGF-1R in the regulation of Id gene expression and the stabilization of Ras are findings original in our laboratory and completely novel. The role of p66 in IGF-IR signaling has been studied in other laboratories as well as ours, but very little information has emerged so far. The combination of a receptor and three signaling proteins all involved in aging constitute an area of investigation, that combines basic cell biology and relevance to aging. This project requires a close interaction with at least two other projects in the present application.

描述（由申请人提供）：1型胰岛素样生长因子

项目成果

24p3 in differentiation of myeloid cells.

24p3 在骨髓细胞分化中的作用。

• DOI: 10.1002/jcp.20400
• 发表时间: 2005
• 期刊: Journal of cellular physiology
• 影响因子: 5.6
• 作者: Liu,Mingli;Prisco,Marco;Drakas,Robert;Searles,David;Baserga,Renato
• 通讯作者: Baserga,Renato