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CELL AND MOLECULAR BIOLOGY OF ACUTE LEUKEMIA

CELL AND MOLECULAR BIOLOGY OF ACUTE LEUKEMIA
急性白血病的细胞和分子生物学
批准号:
2100705
负责人:
HARVEY D PREISLER
金额:
$31.81万
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-08-01 至 1997-05-31

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中文摘要
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英文摘要
This grant will address several aspects of the potential affects of bioactive agents on leukemia cells in vivo. Leukemia cells will be obtained before and after administration of these agents and the effects of these agents on the distribution of cell cycle times amongst the leukemia cells within individual patients will be explored. The effects of these agents on the expression of the protooncogenes fms, myb, IL1beta and myc will be studied as well. Initially, we will study the effects of retinoic acid/interferon and rhGM-CSF. The studies will be extended to other agents once these initial studies are completed. Parallel evaluation of the bioactive agents in vitro will be conducted so that predictive in vitro assays can be developed.
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海外基金