Robust purification of a hight value lipopeptide

EnzBond创造了一条获得高价值脂肽制药产品的新途径，但由于产品非常粘性，在最后一步的提纯和处理中遇到了瓶颈。产品的“粘性”是大分子结构胶束形成的结果，这是用我们目前的方法很难研究的。最终的结果是严重的下游问题，如柱堵塞和由于杂质被捕获而进行的多轮纯化。与NPL合作，将更好地了解胶束的物理性质，并将开发新的纯化方法。在项目结束时，EnzBond将有一个创新的连续工艺来生产超纯脂肽，而不会出现已知的问题。

EnzBond has created a novel route to a high value lipid-peptide pharmaceutical product and a bottle neck has been reached in the final step purification and handling as the product is very sticky. The "stickiness" of the product is a result of a macro-molecular structure, micelle, forming which is difficult to study using our current methods. The end result is significant downstream issues such as column blockage and multiple rounds of purification due to impurities being trapped. In collaboration with NPL, the physics of the micelle will be better understood and novel purification methods will be developed. At the end of the project EnzBond will have an innovative continuous process to produce a ultra-pure lipopeptide without the known issues arising.