CellulaREvolution: Bringing Continuous Processing to Cell Manufacture

CellulaREvolution：将连续处理引入电池制造

• 批准号: 105114
• 金额: $ 14.81万
• 依托单位: CELLULAREVOLUTION
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=105114
• 关键词: CellulaREvolution; Bringing; Continuous; Processing; Cell

"There are a number of well-established and emerging commercial markets exploiting scientific advances in growing living cells to 'manufacture' new products, including pharmaceutical drugs, stem cells, gene therapies and cell-based meat. Companies working on these developments are addressing some of the major challenges facing the world over the coming decades, such as global hunger, global warming and pandemic threats.Many of these applications rely on the use of adherent cells (cells requiring a solid surface on which to grow, such as the bottom of a culture flask). The standard approach to growing adherent cells has not changed in 50 years; cells are grown in batches, the size of each batch limited by the surface area upon which the cells are attached (_e.g_. flask size). Critically, traditional batch bioprocessing techniques for the culture of adherent cells cannot meet current demands (typical lot sizes are 10e^10 cells but needs in some markets are more in the range of 10e^30) and is therefore a significant bottleneck to the future commercial potential of companies that produce or use adherent cells.A radical departure from traditional engineering solutions is required, _i.e_. an alternative to simply increasing surface area by using microcarriers, hollow fibres or multi-layered flasks, as these approaches can never practically meet the growing demand. At CellulaREvolution we aim at establishing a revolutionary method to culture adherent cells in serum-free medium. Our novel approach is to move from the traditional batch culture (with its overly complicated ways to increase surface area) to a simple continuous culture system where cells are produced unremittingly. Our innovation facilitates such an approach for the first time.In light of this, the current proposal will enable the setting up of CellulaREvolution as a business via the appointment of a CEO, hiring qualified team members, renting lab/office space, paying for consultancy, legal costs and further market research. Accelerating the company development at this stage, will help CellulaREvolution to attract private investors to financially support initial development and sales of its products."

“有一些成熟的和新兴的商业市场利用科学进步，在生长活细胞，以'制造'新产品，包括药物，干细胞，基因疗法和细胞为基础的肉。致力于这些开发的公司正在应对未来几十年世界面临的一些重大挑战，例如全球饥饿，全球变暖和流行病威胁。这些应用中的许多应用依赖于贴壁细胞（细胞需要在固体表面上生长，例如培养瓶的底部）的使用。培养贴壁细胞的标准方法50年来没有改变;细胞分批培养，每批细胞的大小受细胞附着的表面积限制（例如，烧瓶尺寸）。重要的是，传统的贴壁细胞培养的批量生物处理技术不能满足当前的需求（典型的批量大小为10e^10个细胞，但在某些市场的需求更在10e^30的范围内），因此是生产或使用贴壁细胞的公司未来商业潜力的一个重大瓶颈。这是通过使用微载体、中空纤维或多层烧瓶来简单地增加表面积的替代方案，因为这些方法实际上永远不能满足不断增长的需求。在CellulaREvolution，我们的目标是建立一种革命性的方法，在无血清培养基中培养贴壁细胞。我们的新方法是从传统的分批培养（以其过于复杂的方式增加表面积）转移到一个简单的连续培养系统，在该系统中细胞不断地产生。我们的创新首次促成了这种方法。有鉴于此，目前的提案将通过任命首席执行官，雇用合格的团队成员，租用实验室/办公室空间，支付咨询费，法律的费用和进一步的市场研究来建立CellulaREvolution作为一家企业。在现阶段加速公司发展，将有助于CellulaREvolution吸引私人投资者，为其产品的初步开发和销售提供资金支持。"