LONGITUDINAL ANALYSIS OF ASR FOLLOWING PRENATAL COCAINE

产前接触可卡因已被证明会产生 人类和实验动物的神经行为变化。在……里面 矛盾的发现表明影响微乎其微，而且 转瞬即逝。这种差异的基础是CNS等问题 在发育的关键时期暴露，受试者的年龄 评估，以及选择有效的神经行为测量。 声学惊吓反应(ASR)被广泛认为是一种衡量 中枢神经系统功能。由于ASR的感觉和运动部件对 毒物的影响，因为反应性能受到影响 随着年龄的增长，ASR被选为纵向的功能指标 产前可卡因的影响。一种客观、细粒度的ASR分析 被认为能够区分由于以下原因引起的行为变化 正常衰老的长期变化与产前药物暴露有关。 暴露于可卡因的大鼠的年龄*治疗交互作用是可预见的。 怀孕大鼠分组口服25或50毫克/公斤 从怀孕6天到20天，每天服用可卡因。2，8天后进行ASR检查， 14&20个月龄的子代。主题回复将被转换 转换成电信号，数字化，并通过计算机处理。在……里面 除了传统的措施外，全面的全波分析 将会被执行。隔离主体组件和系统组件的技术 都是有用的。

Prenatal exposure to cocaine has been demonstrated to produce neurobehavioral changes in humans and laboratory animals. In contradiction are findings that suggest the effects are minimal and transient. At the base of this discrepancy are issues such as CNS exposure during critical periods of development, the age of subject assessment, and the selection of valid neurobehavioral measures. The acoustic startle response (ASR) is widely regarded as a measure of CNS function. Since sensory and motor components of ASR are sensitive to the effects of toxicants, and because response performance is affected by aging, ASR was selected as a functional index of the longitudinal effects of prenatal cocaine. An objective and fine-grained ASR analysis is regarded as capable of differentiating behavioral changes due to normal aging from long-term changes related to prenatal drug exposures. Age * Treatment interactions are anticipated for cocaine-exposed rats. Groups of pregnant rats will be orally administered 25 or 50 mg/kg cocaine daily from gestation days 6 to 20. ASR will be examined in 2, 8, 14, & 20 month-old offspring groups. Subject responses will be converted to an electrical signal, digitized, and processed via computer. In addition to traditional measures, a comprehensive whole wave analysis will be performed. Techniques to isolate subject and system components are use.