ONE JOULE DIODE LASER FOR GLAUCOMA TREATMENT

尖顶最近的发展导致了三焦耳的可用 脉冲半导体激光器阵列。拟议的第一阶段研究研究是设计的 为了确定廉价光纤耦合的可行性，两个- 产生1焦耳脉冲能量的维度激光二极管阵列 在巩膜组织中汽化和钻孔巩膜组织中的巩膜组织 厌色染料如吲哚青绿。与商业上的现在不同 现有的连续波半导体激光器只对组织进行光凝， 拟议中的装置将产生足够的能量来精确汽化 用一次激光脉冲就可以染上软组织。单脉冲仪器 1焦耳的峰值功率在800纳米处现在还没有商业化。 将要使用的激光器设计将结合圆柱形阵列 微透镜，用于准直二极管阵列的输出，将其聚焦成 光纤。 设想的半导体激光仪器将对两种侵入性 和非侵入性的内部巩膜造口术以及外部 结膜下巩膜造口术。因此，它将是一款多功能和高度 治疗难治性开角型青光眼的有用装置。这个 同样的仪器也可能对其他青光眼治疗有用。 手术，如小梁成形术和经巩膜 睫状光凝固。 初步研究表明，有可能获得足够的 人巩膜组织中可以实现汽化的嫌色物质 激光能量为800 nm的1焦耳脉冲。

Recent developments at Spire have led to the availability of three joule pulsed diode laser arrays. The proposed Phase I research study is designed to establish the feasibility of an inexpensive fiber-coupled, two- dimensional laser diode array generating one joule of pulsed energy to vaporize and drill sclerostomies in scleral tissue prestained with a chromophobe such as indocyanine green dye. Unlike present commercially available continuous-wave diode lasers which only photocoagulate tissue, the proposed device would generate sufficient energy to precisely vaporize stained soft tissue with a single laser pulse. Single-pulse instruments with one joule of peak power at 800 nm are not now commercially available. The laser design to be used would incorporate arrays of cylindrical microlenses to collimate the output of a diode array, focusing it into an optical fiber. The envisioned diode laser instrument would be useful for both invasive and non-invasive internal sclerostomy procedures, as well as external subconjunctival sclerostomies. As such, it would be a versatile and highly useful device for the treatment of refractory open-angle glaucoma. The same instrument may also prove useful for other glaucoma treatment procedures, such as trabeculoplasty and transscleral cyclophotocoagulation. Preliminary studies indicate that it is possible to obtain sufficient chromophobe in human scleral tissue that vaporization can be accomplished with a one joule pulse of 800 nm laser energy.