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ONE JOULE DIODE LASER FOR GLAUCOMA TREATMENT

用于青光眼治疗的一焦耳二极管激光器

基本信息

批准号：
2164356
负责人：
KURT J LINDEN
金额：
$ 7.49万
依托单位：
SPIRE CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-07-15 至 1995-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2164356
关键词：
biomedical equipment development eye laser surgery fiber optics glaucoma surgery human tissue indocyanine green lasers method development photocoagulation therapy stainings

项目摘要

Recent developments at Spire have led to the availability of three joule pulsed diode laser arrays. The proposed Phase I research study is designed to establish the feasibility of an inexpensive fiber-coupled, two- dimensional laser diode array generating one joule of pulsed energy to vaporize and drill sclerostomies in scleral tissue prestained with a chromophobe such as indocyanine green dye. Unlike present commercially available continuous-wave diode lasers which only photocoagulate tissue, the proposed device would generate sufficient energy to precisely vaporize stained soft tissue with a single laser pulse. Single-pulse instruments with one joule of peak power at 800 nm are not now commercially available. The laser design to be used would incorporate arrays of cylindrical microlenses to collimate the output of a diode array, focusing it into an optical fiber. The envisioned diode laser instrument would be useful for both invasive and non-invasive internal sclerostomy procedures, as well as external subconjunctival sclerostomies. As such, it would be a versatile and highly useful device for the treatment of refractory open-angle glaucoma. The same instrument may also prove useful for other glaucoma treatment procedures, such as trabeculoplasty and transscleral cyclophotocoagulation. Preliminary studies indicate that it is possible to obtain sufficient chromophobe in human scleral tissue that vaporization can be accomplished with a one joule pulse of 800 nm laser energy.

Spire的最新发展使三焦耳的可用性脉冲二极管激光器阵列拟议的I期研究旨在为了建立廉价的光纤耦合的可行性，两个- 三维激光二极管阵列产生一焦耳的脉冲能量，在巩膜组织中汽化和钻孔巩膜造口术，例如吲哚菁绿色染料。与目前商业上可用的仅光凝固组织的连续波二极管激光器，所提出的装置将产生足够的能量，用单激光脉冲染色软组织。单脉冲仪器在800 nm处具有1焦耳峰值功率的激光器现在还不能在市场上买到。要使用的激光器设计将包括圆柱形阵列，微透镜准直二极管阵列的输出，将其聚焦到光纤设想的二极管激光仪器将是有用的，和非侵入性的内部巩膜造口术程序，以及外部结膜下巩膜造口术因此，它将是一个多功能和高度治疗难治性开角型青光眼的有效装置。的同样的仪器也可以证明对其它青光眼治疗有用手术，如小梁成形术和经巩膜睫状体光凝术初步研究表明，有可能获得足够的在人类巩膜组织中的一种嫌色物，用800纳米激光能量的一焦耳脉冲。