BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION (BARI

旁路血管成形术血运重建研究（BARI）是一项 前瞻性多中心、随机临床试验经皮 腔内冠状动脉成形术（PTCA）与冠状动脉的比较 动脉搭桥手术（CABG）。 加拿大 III 级或 静脉心绞痛和心肌梗塞后状态的患者 患有适当的多支冠状动脉疾病的患者将 随机接受 PTCA 或 CABG。 为期2年的招聘和 需要5年的随访期。 主要终点为 试验将是死亡率和心肌梗塞。 为了 检测 2,000 名患者将采取的干预措施之间的差异 被随机化。 将研究这些干预措施的其他结果 包括：1) 缓解心绞痛，2) 左心室休息和锻炼 功能，3) 血运重建的完整性，4) 复发率， 5) 交叉率，6) 成本，7) 记忆和认知能力，以及 8）生活质量。 数据分析还将重点关注几个方面 重要的子集，包括这些患者：1）近期状态 心肌梗塞，2) 年龄超过 65 岁，3) 左近端 前降动脉狭窄，4) 不稳定型心绞痛 5) 慢性 完全闭塞，6) 左心室功能受损。 的 该试验的结果预计将有助于确定最佳方案 PTCA和CABG介入策略的应用。

The bypass angioplasty revascularization investigaiton (BARI) is a prospective multicenter, randomized clinical trial of percutaneous transluminal coronary angioplasty (PTCA) compared to coronary artery bypass surgery (CABG). Patients with Canadian Class III or IV angina, and patients who are status-post myocardial infarction with suitable multivessel coronary artery disease will be randomized to receive PTCA or CABG. A 2 year recruitment and 5 year follow-up period will be required. The major endpoints for the trial will be mortality and myocardial infarction. In order to detect a difference between the interventions 2,000 patients will be randomized. Other outcomes which will be studied for these intervention inclued: 1) relief of angina, 2) rest and exercise left ventricular function, 3) completeness of revascularization, 4) recurrence rate, 5) corssover rate, 6) cost, 7) memory and cognitive abilities, and 8) quality of life. The date analysis will also focus on several important subsets including those patients: 1) status-post recent myocardial infarction, 2) age over 65 years, 3) proximal left anteriaor descending artery stenosis, 4) unstable angina 5) chronic total occlusion, and 6) imparied left ventricular function. The results of this trial are expected to help delineate the optimal application of the PTCA and CABG interventional strategies.