BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION (BARI

旁路血管成形术血运重建研究(BARI)是一项 经皮穿刺术的前瞻性多中心随机临床试验 冠状动脉腔内成形术(PTCA)与冠状动脉成形术的比较 动脉搭桥术(CABG)。患有加拿大III级或以上的患者 静脉型心绞痛，以及处于心肌梗塞后状态的患者 有了合适的多支冠状动脉疾病 随机接受PTCA或CABG。A两年招聘和 需要5年的随访期。的主要终端 这项试验将是死亡率和心肌梗死。为了 检测干预措施之间的差异2,000名患者将 随机化。 将为这些干预研究的其他结果 包括：1)缓解心绞痛，2)休息和锻炼左心室 功能，3)血运重建的完全性，4)复发率， 5)交叉率，6)成本，7)记忆和认知能力，以及 8)生活质量。数据分析还将重点放在几个 重要的子集，包括这些患者：1)状态--最近发布 心肌梗死，2)年龄超过65岁，3)左侧近端 前降支狭窄，4)不稳定型心绞痛5)慢性 完全闭塞，6)左心功能受损。这个 这项试验的结果有望帮助描绘出最佳的 PTCA和CABG介入策略的应用。

The bypass angioplasty revascularization investigaiton (BARI) is a prospective multicenter, randomized clinical trial of percutaneous transluminal coronary angioplasty (PTCA) compared to coronary artery bypass surgery (CABG). Patients with Canadian Class III or IV angina, and patients who are status-post myocardial infarction with suitable multivessel coronary artery disease will be randomized to receive PTCA or CABG. A 2 year recruitment and 5 year follow-up period will be required. The major endpoints for the trial will be mortality and myocardial infarction. In order to detect a difference between the interventions 2,000 patients will be randomized. Other outcomes which will be studied for these intervention inclued: 1) relief of angina, 2) rest and exercise left ventricular function, 3) completeness of revascularization, 4) recurrence rate, 5) corssover rate, 6) cost, 7) memory and cognitive abilities, and 8) quality of life. The date analysis will also focus on several important subsets including those patients: 1) status-post recent myocardial infarction, 2) age over 65 years, 3) proximal left anteriaor descending artery stenosis, 4) unstable angina 5) chronic total occlusion, and 6) imparied left ventricular function. The results of this trial are expected to help delineate the optimal application of the PTCA and CABG interventional strategies.