BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION (BARI

旁路血管成形术血运重建研究（BARI

• 批准号: 3553064
• 负责人: BERTRAM PITT
• 金额: $ 21.54万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1994-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553064
• 关键词: angina pectoris; angiocardiography; cardiovascular stress test; clinical trials; coronary bypass; coronary occlusion /thrombosis; heart catheterization; heart output disorder; human old age (65+); human subject; human therapy evaluation; intraluminal angioplasty; longitudinal human study; myocardial infarction; patient /disease registry; radiocardiography

The bypass angioplasty revascularization investigaiton (BARI) is a prospective multicenter, randomized clinical trial of percutaneous transluminal coronary angioplasty (PTCA) compared to coronary artery bypass surgery (CABG). Patients with Canadian Class III or IV angina, and patients who are status-post myocardial infarction with suitable multivessel coronary artery disease will be randomized to receive PTCA or CABG. A 2 year recruitment and 5 year follow-up period will be required. The major endpoints for the trial will be mortality and myocardial infarction. In order to detect a difference between the interventions 2,000 patients will be randomized. Other outcomes which will be studied for these intervention inclued: 1) relief of angina, 2) rest and exercise left ventricular function, 3) completeness of revascularization, 4) recurrence rate, 5) corssover rate, 6) cost, 7) memory and cognitive abilities, and 8) quality of life. The date analysis will also focus on several important subsets including those patients: 1) status-post recent myocardial infarction, 2) age over 65 years, 3) proximal left anteriaor descending artery stenosis, 4) unstable angina 5) chronic total occlusion, and 6) imparied left ventricular function. The results of this trial are expected to help delineate the optimal application of the PTCA and CABG interventional strategies.

旁路血管成形术重建术（BARI）是一项重要的临床研究