BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION (BARI

旁路血管成形术再血管化研究（巴里）是一项 前瞻性多中心、随机临床试验，经皮 经腔冠状动脉成形术（PTCA）与冠状动脉 动脉旁路手术（CABG）。 加拿大III类或 IV型心绞痛和心肌梗死后状态的患者 多支冠状动脉疾病的患者 随机接受PTCA或CABG。 2年招聘， 需要5年随访期。 主要终点 试验将是死亡率和心肌梗死。 为了 检测干预措施之间的差异，2,000名患者将 是随机的。 这些干预措施将研究的其他结果 包括：1）缓解心绞痛，2）休息和运动左心室 功能，3）血运重建的完整性，4）复发率， 5)交叉率，6）成本，7）记忆和认知能力，以及 8)生活质量 数据分析还将集中在几个方面 重要的亚组包括以下患者：1）状态-近期 心肌梗死，2）年龄超过65岁，3）左近端 前降支狭窄，4）不稳定型心绞痛，5）慢性 完全闭塞; 6）左室功能损害。 的 这项试验的结果预计将有助于描绘最佳的 PTCA和CABG介入策略的应用。

The bypass angioplasty revascularization investigaiton (BARI) is a prospective multicenter, randomized clinical trial of percutaneous transluminal coronary angioplasty (PTCA) compared to coronary artery bypass surgery (CABG). Patients with Canadian Class III or IV angina, and patients who are status-post myocardial infarction with suitable multivessel coronary artery disease will be randomized to receive PTCA or CABG. A 2 year recruitment and 5 year follow-up period will be required. The major endpoints for the trial will be mortality and myocardial infarction. In order to detect a difference between the interventions 2,000 patients will be randomized. Other outcomes which will be studied for these intervention inclued: 1) relief of angina, 2) rest and exercise left ventricular function, 3) completeness of revascularization, 4) recurrence rate, 5) corssover rate, 6) cost, 7) memory and cognitive abilities, and 8) quality of life. The date analysis will also focus on several important subsets including those patients: 1) status-post recent myocardial infarction, 2) age over 65 years, 3) proximal left anteriaor descending artery stenosis, 4) unstable angina 5) chronic total occlusion, and 6) imparied left ventricular function. The results of this trial are expected to help delineate the optimal application of the PTCA and CABG interventional strategies.