IGF-II AND MUSCLE CELL DIFFERENTIATION

IGF-II 和肌肉细胞分化

• 批准号: 2143595
• 负责人: STEPHEN M ROSENTHAL
• 金额: $ 10.28万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2143595
• 关键词: IGF; II; MUSCLE; CELL; DIFFERENTIATION

项目成果

Skeletal muscle cell-derived insulin-like growth factor (IGF) binding proteins inhibit IGF-I-induced myogenesis in rat L6E9 cells.

骨骼肌细胞衍生的胰岛素样生长因子 (IGF) 结合蛋白抑制大鼠 L6E9 细胞中 IGF-I 诱导的肌生成。

• DOI: 10.1210/endo.136.2.7530651
• 发表时间: 1995
• 期刊: Endocrinology.
• 作者: Silverman,LA;Cheng,ZQ;Hsiao,D;Rosenthal,SM
• 通讯作者: Rosenthal,SM

Mechanisms of insulin-like growth factor (IGF)-II-induced IGF-I receptor down-regulation in BC3H-1 muscle cells.

BC3H-1 肌细胞中胰岛素样生长因子 (IGF)-II 诱导 IGF-I 受体下调的机制。

• DOI: 10.1677/joe.0.1410069
• 发表时间: 1994
• 期刊: The Journal of endocrinology
• 作者: Rosenthal,SM;Brown,EJ
• 通讯作者: Brown,EJ

Opposing early and late effects of insulin-like growth factor I on differentiation and the cell cycle regulatory retinoblastoma protein in skeletal myoblasts.

胰岛素样生长因子 I 对骨骼肌母细胞分化和细胞周期调节视网膜母细胞瘤蛋白的早期和晚期作用相反。

• DOI: 10.1073/pnas.92.22.10307
• 发表时间: 1995
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Rosenthal,SM;Cheng,ZQ
• 通讯作者: Cheng,ZQ

An insulin-like growth factor-II (IGF-II) analog with highly selective affinity for IGF-II receptors stimulates differentiation, but not IGF-I receptor down-regulation in muscle cells.

对 IGF-II 受体具有高度选择性亲和力的胰岛素样生长因子-II (IGF-II) 类似物可刺激肌肉细胞分化，但不会下调 IGF-I 受体。

• DOI: 10.1210/endo.135.1.8013373
• 发表时间: 1994
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Rosenthal,SM;Hsiao,D;Silverman,LA
• 通讯作者: Silverman,LA