Enabling the bioeconomy with a platform production and integrated separation technology

通过平台生产和集成分离技术实现生物经济

• 批准号: 105375
• 金额: $ 26.61万
• 依托单位: HOLIFERM LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=105375
• 关键词: Enabling; bioeconomy; platform; production; integrated

"For many applications biobased chemicals produced by fermentation have enhanced functionality compared to petrochemically derived products but are significantly more expensive to manufacture and are therefore only used in niche applications. Most surfactants in use in the cosmetic industry are currently oil-based irritants, and many in the agricultural market are toxic endocrine disruptors, with bans coming into place for some of these surfactants. There is also a strong customer driver for improved performance and green surfactants.We have developed a technique to reduce production costs for biobased chemicals produced by fermentation by around 40%. Fermentations use microorganisms to convert renewable raw materials into a biochemical product in a large stainless-steel vessel. During fermentation the bioproduct accumulates, causing mixing and other problems, and resulting in the fermentation having to be stopped. The novel gravity-based separation system we have developed can recover the product as it is produced, preventing the negative effects of product accumulation and allowing process intensification. The use of the technology can triple the output from a given vessel, reducing capital expenditure requirements 3x.This technology has been demonstrated fully for one biosurfactant product, sophorolipid, for which we have performed scale up trials in collaboration with several active companies. We are now scaling up the technology for industrial production and applying the technology across a whole range of lipid bioproducts.In this project, we aim to reach a pre-industrial validation of our technology with sophorolipid with a system configured for industrial use and a 750 l bioreactor. Whilst other integrated separation technologies have often been shown to be successful at lab scale, few are scaled up due to cost and complexity, and while we have already reached pilot scale a pre industrial validation will be another important milestone. We will also aim to demonstrate a 50% performance improvement with a second bioproduct, mannosylerithritol lipids, at laboratory scale, and generate a proof of principle, with a third product, rhamnolipids. As importantly, we will be building a team capable of delivering this project and subsequently developing a successful business. This will allow our company to be derisked to a sufficient extent to attract significant financial investment, as well as fully paying clients. This project contributes towards facilitating a move towards a circular bioeconomy and increased UK productivity in line with the UK bioeconomy and industrial strategies."

“与石油化学衍生产品相比，通过发酵生产的生物基化学品在许多应用中具有增强的功能，但制造成本要高得多，因此仅用于小众应用。目前，化妆品行业使用的大多数表面活性剂都是油基刺激物，农业市场上的许多表面活性剂是有毒的内分泌干扰物，其中一些表面活性剂已被禁止使用。此外，客户对改进性能和绿色表面活性剂也有强烈的需求。我们已经开发出一种技术，可以将发酵生产的生物基化学品的生产成本降低约40%。发酵利用微生物在一个大型不锈钢容器中将可再生原料转化为生化产品。在发酵过程中，生物产物积累，引起混合和其他问题，并导致发酵不得不停止。我们开发的新型重力分离系统可以在产品生产时回收产品，防止产品积累的负面影响，并允许过程强化。使用该技术可以将给定船舶的产量提高三倍，将资本支出降低三倍。这项技术已经在一种生物表面活性剂产品sophorolipid上得到了充分的证明，我们已经与几家活跃的公司合作进行了大规模试验。我们现在正在扩大工业生产技术的规模，并将该技术应用于整个脂质生物产品系列。在这个项目中，我们的目标是通过一个配置用于工业用途的系统和一个750升的生物反应器，对我们的槐脂技术进行工业化前的验证。虽然其他集成分离技术在实验室规模上经常被证明是成功的，但由于成本和复杂性，很少能扩大规模，虽然我们已经达到了中试规模，但工业化前的验证将是另一个重要的里程碑。我们还将致力于在实验室规模上展示第二种生物产品甘露糖基四醇脂的50%性能改进，并利用第三种产品鼠李糖脂进行原理验证。同样重要的是，我们将建立一个能够交付这个项目的团队，并随后发展成功的业务。这将使我们的公司在足够的程度上降低风险，以吸引大量的金融投资，以及全额付款的客户。该项目有助于促进向循环生物经济的转变，并根据英国生物经济和工业战略提高英国的生产力。”