腐蚀艾克内拉的抗原和细胞毒性活性-猫眼课题宝

腐蚀艾克内拉的抗原和细胞毒性活性

批准号：

2132357

负责人：

MARTIN LEVINE

金额：

$3.65万

依托单位：

UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

依托单位国家：

美国

项目类别：

财政年份：

1995

资助国家：

美国

项目状态：

已结题

起止时间：

1995-03-01 至 1997-02-28

来源：

https://reporter.nih.gov/project-details/2132357

项目摘要

项目成果

MARTIN LEVINE的其他基金

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中文摘要

翻译

描述：此修订后的申请描述了设计的实验

英文摘要

DESCRIPTION: This revised application describes experiments designed to clarify therole of a protein produced by E. corrodens which has been implicated as a toxin with effects on human epithelial cells, fibroblasts, and HL60 cells.A monoclonal antibody has been identified which blocks the toxic activities of the organism, and that Mab reacts with an approximately 72Kd molecule produced by E. corrodens. Interestingly, the Mab also cross-reacts with a protein of apparently 140Kd produced by S. sanguis. Antisera reactive to the 140Kd protein also react with the E. corrodens 72Kd molecule. The experimental plan described in this application is to clone and inactivate the gene encoding the 72Kd molecule from E. corrodens and evaluate the effects of its inactivation on the toxicity in various cell culture systems.

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