STREPTOCOCCUS SANGUIS MICROBIAL GENOME PROJECT

血链球菌微生物基因组计划

• 批准号: 6379870
• 负责人: FRANCIS L. MACRINA
• 金额: $ 28.55万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379870
• 关键词: Streptococcus sanguis; bacterial genetics; genome; nucleic acid sequence; nucleotides

DESCRIPTION (Adapted from the Investigator's Abstract): The investigators propose to determine the nucleotide sequence of the genome of Streptococcus sanguis. This member of the human indigenous oral microflora has long been recognized as a key player in the bacterial colonization of the mouth. It directly binds to oral surfaces and serves as a tether for the attachment of a variety of other oral microorganisms which colonize the tooth surface, form dental plaque, and contribute to the etiology of both caries and periodontal disease. Furthermore, S. sanguis has been long recognized as a leading cause of bacterial endocarditis, a disease of high morbidity which is fatal if untreated. Moreover, S. sanguis and other viridans streptococci of the mouth are emerging as life-threatening bloodstream pathogens in neutropenic patients. And such infections are being compounded by the increasing frequency with which penicillin resistance is being observed in this group of organisms. New knowledge about this organism could be used in controlling oral microbial colonization so as to minimize or eliminate plaque-related oral diseases. Since the mouth is the source of S. sanguis isolates that cause endocarditis and bacteremia, novel controlling strategies also would have an impact on systemic infections. S. sanguis genomic data will provide new insights into this organism's lifestyle and virulence properties that cannot be extrapolated from analyzing the genomic data of even closely related species. The investigators believe that the complete genomic structure of S. sanguis is certain to lead to the discovery of new genes, insights into their regulation, and an appreciation of their interactions at both the genotypic and phenotypic levels. This, in turn, will provide researchers with new targets for vaccines and rationally designed drugs.

描述（改编自研究者摘要）：研究者 建议确定链球菌基因组的核苷酸序列 血。这种人类本土口腔微生物群落的成员长期以来一直是 被认为是口腔细菌定植的关键因素。它 直接结合到口腔表面，并作为连接 各种其它口腔微生物在牙齿表面定居， 牙菌斑，并有助于龋齿和牙周病的病因 疾病此外，S.长期以来，血吸虫病一直被认为是导致 细菌性心内膜炎是一种高发病率的疾病，如果 未经治疗。此外，S.血链球菌和其他口腔草绿色链球菌 正在作为威胁生命的血流病原体出现在血小板减少症患者中。 而这种感染正因越来越频繁的 在这组微生物中观察到青霉素耐药性。新 关于这种微生物知识可用于控制口腔微生物， 从而最小化或消除牙菌斑相关的口腔疾病。以来 口是S的来源。引起心内膜炎的血液分离株， 菌血症，新的控制策略也会对全身性 感染. S. sanguis基因组数据将为这一点提供新的见解 生物体的生活方式和毒力特性，不能从 分析甚至是密切相关物种的基因组数据。调查人员 认为S.血肯定会导致 新基因的发现，对它们的调节的见解，以及对 它们在基因型和表型水平上的相互作用。而这 反过来，将为研究人员提供新的疫苗靶点， 设计药物