Defining signals that regulate intestinal stem cells during organ growth

该项目将确定在干细胞中促进细胞分裂的关键信号，干细胞产生肠道内上皮层。这一基础知识具有重要意义，因为它将提供有关关键信号如何传递的信息，以促进这一关键细胞层的损伤修复。肠道是跨物种保存的重要器官，当它暴露在非常恶劣的细菌和食物消化产物的环境中时，容易受到伤害。该项目的成果将提供对上皮衬里的发育和再生的了解，以及可能增强修复的关键信号。未来的好处包括改善动物和人类的健康结果，以及潜在的经济利益。

This project will define the key signals that promote cell division in the stem cells which produce the inner epithelial lining of the gut. This fundamental knowledge is of significance as it will provide information about how key signals are delivered to promote repair of injury to this key cell layer. The gut is a vital organ conserved across species that is prone to injury as it is exposed to a very harsh environment of bacteria and the products of food digestion. The outcomes of this project will provide an understanding of development and regeneration of the epithelial lining and key signals that may augment repair. The future benefits include improved health outcomes for animals and humans and potential economic benefits.