PSYCHIATRIC SYMPTOMS IN ALZHEIMERS DISEASE

这份提案描述了戴维·L·李的职业发展计划。 Sultzer，M.D.，并请求美国政府再支持两年 老年精神病学临床精神卫生学术奖。Dr。 苏尔策于1991年获得了为期三年的学术奖。成就 在加州大学洛杉矶分校该项目的最初三年中，包括： 1.研究生产力。特定精神症状的严重性 对61例阿尔茨海默病(AD)患者进行了检查。一个 阿尔茨海默病患者与非阿尔茨海默病患者的精神症状比较 血管性痴呆表明，抑郁、焦虑和行为 血管性痴呆患者的发育迟缓更为严重。一个 正电子发射断层扫描(PET)研究表明，大脑皮质 新陈代谢不足与认知和非认知有关 阿尔茨海默病患者的精神症状。初步证据表明 额叶皮质的低代谢显著影响了 躁动和精神错乱症状。这些研究的结果是 在国家会议上提出，目前正在出版、出版或 投降。 2.学术发展。苏尔策博士已经掌握了PET的基本技能 已完成生物统计学和生物统计学的课程 研究设计，并提升了自己的教学技能。他被认为是 作为老年精神健康领域的一位有前途的学术领袖。 拟议的两年计划建立在研究进展和 在最初的颁奖期间培养的学术技能。 具体目标是：1)检查精神健康的后果 阿尔茨海默病患者的额叶功能障碍，以及2)获得晚期 具备PET成像和数据分析方面的研究技能。 为实现这些目标，建议开展以下活动。 1.苏尔策博士将实施研究项目：额叶 阿尔茨海默病的功能障碍。这项研究考察了纵向的 阿尔茨海默病患者额叶低代谢的过程，并验证以下假设 阿尔茨海默病特定精神症状的进展与 额叶皮质代谢减少。这项研究还检查了 额叶低代谢对养老院安置风险的影响 以及抗精神病药物的使用。 2.苏尔策博士将完成PET方面的额外重点培训 方法论和神经图像分析，将指导团契学员 在加州大学洛杉矶分校从事他们的研究项目，并将成为 精神疾病的现象学、病理生理学和治疗 阿尔茨海默病症状。

This proposal describes the career development program of David L. Sultzer, M.D., and requests two additional years of support by the Clinical Mental Health Academic Award in Geriatric Psychiatry. Dr. Sultzer received the three-year Academic Award in 1991. Accomplishments during the initial three years of the program at UCLA include: 1. Research productivity. The severity of specific psychiatric symptoms in 61 patients with Alzheimer's disease (AD) has been examined. A comparison of psychiatric symptoms in patients with AD and those with vascular dementia has shown that depression, anxiety, and behavioral retardation are more severe in patients with vascular dementia. A positron emission tomography (PET) study has shown that cortical hypometabolism is associated with both cognitive and noncognitive psychiatric symptoms in patients with AD. Preliminary evidence suggests that hypometabolism in the frontal cortex contributes prominently to agitation and psychotic symptoms. Results from these studies have been presented at national meetings and are currently published, in press, or in submission. 2. Academic development. Dr. Sultzer has gained basic skills in PET imaging techniques, has completed coursework in biostatistics and research design, and has advanced his teaching skills. He is regarded as a promising academic leader in geriatric mental health. The proposed two-year program builds on the research progress and the academic skills that were developed during the initial Award period. Specific goals are: 1) to examine the mental health consequences of frontal lobe dysfunction in patients with AD, and 2) to gain advanced research skills in PET imaging and data analysis. The following activities are proposed to achieve these goals. 1. Dr. Sultzer will implement the research project: Frontal Lobe Dysfunction in Alzheimer's Disease. This study examines the longitudinal course of frontal hypometabolism in AD and tests the hypothesis that the progression of specific psychiatric symptoms in AD is associated with metabolic reduction in the frontal cortex. The study also examines the impact of frontal hypometabolism on the risk for nursing home placement and neuroleptic medication use. 2. Dr. Sultzer will complete additional focused training in PET methodology and neuroimage analysis, will supervise fellowship trainees at UCLA in their research projects, and will become a faculty expert in the phenomenology , pathophysiology, and treatment of psychiatric symptoms in AD.