PSYCHIATRIC & BEHAVIORAL DISTURBANCES IN ALZHEIMER'S DIS

拟议的三年多学科计划是为了培养他的学术 发展 具体目标是： 1. 提高适用于心理研究的研究技能 老年人的疾病，特别是阿尔茨海默病。 2. 到 更好地了解精神疾病的现象学和发病机制， AD患者的行为障碍。 3. 促进发展， 一个教师和教师资源领域的痴呆症和 老年精神障碍的神经精神方面。 为实现这些目标提出的计划是： 1. 我们将实施精神和行为障碍， 阿尔茨海默病项目。 这项初步研究将检验这一假设 AD的行为变化特征与 特定脑区的功能障碍。 AD患者将接受 精神和行为症状的结构化评估。 区域 葡萄糖的脑代谢率将通过正电子发射测量 断层扫描（PET）。 数据分析将确定 精神障碍和局部脑代谢障碍。 2. 我们将 追求额外的研究培训，参与合作研究 项目，并咨询专家在老年心理健康研究。 3. 我们将完成临床老年精神病学的额外培训， 将在老年精神病学中承担重要职责 加州大学洛杉矶分校的门诊项目。 4. 我们将分享他的知识， 老年精神障碍的神经生物学方面 学生，实习医生，以及加州大学洛杉矶分校的同事。

The proposed three-year multidisciplinary program is to foster his academic development. Specific goals are: 1. To enhance the research skills that apply to the study of mental disorders in the elderly, particularly Alzheimer's disease. 2. To understand better the phenomenology and pathogenesis of psychiatric and behavioral disturbances in patients with AD. 3. To foster development as a teacher and faculty resource in the areas of dementia and the neuropsychiatric aspects of mental disorders in the elderly. Plans proposed to achieve these goals are: 1. We will implement the Psychiatric and Behavioral Disturbances in Alzheimer's Disease project. This pilot study will test the hypothesis that behavioral changes characteristic of AD are associated with extent of dysfunction in specific brain regions. Patients with AD will undergo structured assessment of psychiatric and behavioral symptoms. Regional cerebral metabolic rates for glucose will be measured by positron emission tomography (PET). Data analysis will identify correlations between psychiatric disturbances and regional cerebral dysmetabolism. 2. We will pursue additional research training, participate in collaborative research projects, and consult with experts in geriatric mental health research. 3. We will complete additional training in clinical geriatric psychiatry and will assume important responsibilities in the Geriatric Psychiatry Outpatient program at UCLA. 4. We will share his knowledge of the neurobiological aspects of mental disorders in the elderly with medical students, physician-trainees, and fellow faculty at UCLA.