PSYCHIATRIC & BEHAVIORAL DISTURBANCES IN ALZHEIMER'S DIS

精神科

• 批准号: 3077858
• 负责人: David Sultzer
• 金额: $ 10.56万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3077858
• 关键词: Alzheimer's disease; aging; behavior disorders; brain disorder diagnosis; brain mapping; brain metabolism; glucose metabolism; human middle age (35-64); human old age (65+); human subject; medical complication; mental disorder diagnosis; neuropsychological tests; positron emission tomography; psychometrics

The proposed three-year multidisciplinary program is to foster his academic development. Specific goals are: 1. To enhance the research skills that apply to the study of mental disorders in the elderly, particularly Alzheimer's disease. 2. To understand better the phenomenology and pathogenesis of psychiatric and behavioral disturbances in patients with AD. 3. To foster development as a teacher and faculty resource in the areas of dementia and the neuropsychiatric aspects of mental disorders in the elderly. Plans proposed to achieve these goals are: 1. We will implement the Psychiatric and Behavioral Disturbances in Alzheimer's Disease project. This pilot study will test the hypothesis that behavioral changes characteristic of AD are associated with extent of dysfunction in specific brain regions. Patients with AD will undergo structured assessment of psychiatric and behavioral symptoms. Regional cerebral metabolic rates for glucose will be measured by positron emission tomography (PET). Data analysis will identify correlations between psychiatric disturbances and regional cerebral dysmetabolism. 2. We will pursue additional research training, participate in collaborative research projects, and consult with experts in geriatric mental health research. 3. We will complete additional training in clinical geriatric psychiatry and will assume important responsibilities in the Geriatric Psychiatry Outpatient program at UCLA. 4. We will share his knowledge of the neurobiological aspects of mental disorders in the elderly with medical students, physician-trainees, and fellow faculty at UCLA.

提议的为期三年的多学科项目是为了培养他的学术能力 发展。具体目标是： 1.加强应用于心智研究的研究技巧 老年人的疾病，特别是阿尔茨海默病。2.至 更好地理解精神病学和精神病学的现象学和发病机制 阿尔茨海默病患者的行为障碍。(三)以发展为导向。 痴呆症领域的教师和教员资源 老年人精神障碍的神经精神病学方面。 为实现这些目标而提出的计划包括： 1.落实精神障碍和行为障碍 阿尔茨海默病项目。这项初步研究将检验这一假设 阿尔茨海默病的行为改变特征与 特定大脑区域的功能障碍。阿尔茨海默病患者将接受 对精神和行为症状的结构化评估。地区性 大脑葡萄糖代谢率将通过正电子发射来测量 断层扫描(PET)。数据分析将确定两者之间的相关性 精神障碍和局部大脑代谢障碍。2.我们会 继续进行额外的研究培训，参与合作研究 项目，并咨询老年心理健康研究方面的专家。3. 我们将完成临床老年精神病学的额外培训，并 将担负起老年精神病学的重要责任 加州大学洛杉矶分校的门诊项目。4.我们将分享他对 老年精神障碍的神经生物学研究 加州大学洛杉矶分校的学生、医生实习生和其他教职员工。