CLINICAL TRIAL OF ACUPUNCTURE FOR COCAINE DEPENDENCE

美沙酮维持计划中的可卡因滥用是 目前还没有有效的治疗方法。多名临床医生 报告和非对照研究表明，耳针 可能对治疗鸦片类药物中的可卡因成瘾有效-和 非鸦片依赖人群。然而，没有证据表明 证实这些疗效声明的对照研究。建议数 这项研究是一项为期八周的随机耳针临床试验 用于治疗美沙酮维持患者的可卡因依赖。 这项研究的具体目的有四个：(A)确定 耳针治疗可卡因的疗效观察 (B)确定禁欲是否 在治疗期间开始的治疗维持在三个月和六个月的随访中- (C)调查治疗反应中的性别差异；及(D) 探讨影响治疗结果的关键因素。222 可卡因依赖、美沙酮维持的患者将按性别分层 并随机分配到用于治疗的区域接受针灸治疗 可卡因成瘾，或两个对照组之一：置针 在耳轮皮下，或放松训练。所有治疗 方案是基于我们的研究进行的初步研究 一群人。每组受试者每天接受治疗，每组5次 一周，在研究的前六周，每周三次 过去两周。经尿毒学筛查证实的可卡因使用将是 主要的结果衡量标准。其他结果衡量标准包括：自我 报告的可卡因使用频率和数量，对药物的渴望 暗示、抑郁、焦虑、应对、改变的动力和合成 成瘾严重指数得分。将收集后续数据 在治疗后三个月和六个月。

Cocaine abuse in methadone maintenance programs is a major problem for which there is currently no effective treatment. A number of clinical reports and uncontrolled studies have suggested that auricular acupuncture may be efficacious for the treatment of cocaine addiction in opiate- and non-opiate-dependent populations. However, there is no evidence from controlled studies substantiating these claims of efficacy. The proposed study is an eight-week randomized clinical trial of auricular acupuncture for the treatment of cocaine dependence in methadone-maintained patients. The specific aims of the study are fourfold: (a) to determine the effectiveness of auricular acupuncture for the treatment of cocaine dependence in this patient population; (b) to determine if abstinence initiated during treatment is maintained at three- and six-month follow- up; (c) to investigate sex differences in response to treatment; and (d) to explore key predictors of treatment outcome. Two hundred and twenty-two cocaine-dependent, methadone-maintained patients will be stratified by sex and randomly assigned to receive acupuncture in regions used to treat cocaine addiction, or one of two control groups: needle insertion subcutaneously in the ear helix, or relaxation training. All treatment protocols are based on preliminary studies conducted by -our research group. Subjects in each group will receive treatment daily, five times per week, for the first six weeks of the study, and three times weekly for the last two weeks. Cocaine use, verified by urine toxicology screens, will be the primary outcome measure. Other outcome measures include: self- reported frequency and amount of cocaine use, craving in response to drug cues, depression, anxiety, coping, motivation for change, and composite scores on the Addiction Severity Index. Follow-up data will be collected at three and six months post-treatment.