ANIMAL MODEL FOR DISORDERS OF ADHESION

子宫内膜异位症、卵巢癌与腹部术后粘连 手术被归类为粘连障碍，是主要原因。 女性的痛苦、不孕不育和死亡。子宫内膜异位症的特点是 异位部位的子宫内膜组织存在于异位部位 子宫，并与痛经、盆腔疼痛和不孕症有关。 虽然它是最常见的妇科疾病，但病因或 这种疾病的发病机制尚不清楚。没有 目前可用于批判性研究的实验系统 子宫内膜细胞黏附机制、免疫调节机制 上皮细胞、基质细胞和免疫细胞与血管内皮生长因子的相互作用 腹膜和卵巢细胞导致这种疾病的发展。 使用腹腔液进行的初步研究 没有子宫内膜异位症使我们能够发展出一种实验性的裸体 卵巢部位的小鼠模型。为建立这一点需要资金 体内模型系统不仅在研究中具有潜在的用途 关于子宫内膜异位症的机制，也参与了对 趋化因子与上皮细胞、基质细胞和淋巴样细胞 互动。这个模型系统的开发可能会有潜力 在卵巢癌等粘连性疾病中的应用 以及腹部手术后的粘连。

Endometriosis, ovarian carcinoma and postoperative adhesions in abdominal surgery are classified as disorders of adhesion and are the major causes of pain, infertility and death in women. Endometriosis is characterized by the presence of endometrial tissue in ectopic sites, outside the uterus and is associated with dysmenorrhea, pelvic pain and infertility. Although it is the most common gynecologic disorder, the etiology or pathogenesis of this disease is poorly understood. There are no experimental systems currently available to critically investigate the mechanisms of endometrial cell adhesion, mediation of immune mechanisms and the interactions of epithelial, stromal and immune cells with the peritoneal and ovarian cells leading the development of this disease. Preliminary studies using peritoneal fluids from individuals with and without endometriosis has enabled us to develop an experimental nude mouse model for ovarian sites. Funds are requested for establishing this in vivo model system which has potential usefulness not only in the study of the mechanisms involved in endometriosis but also in the study of chemotactic factors and the epithelial, stromal and lymphoid cell interactions. Development of this model system may have potential applications in other disorders of adhesions such as ovarian carcinomas and postsurgical adhesions in abdominal surgery.