ANIMAL MODEL FOR DISORDERS OF ADHESION

粘连障碍动物模型

• 批准号: 2284466
• 负责人: P G SATYASWAROOP
• 金额: $ 4.01万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2284466
• 关键词: adhesions; athymic mouse; cell adhesion; chemoattractants; disease /disorder model; endometriosis; epithelium; model design /development; ovary neoplasms; peritoneal fluid; peritoneum; postoperative complications; stromal cells

Endometriosis, ovarian carcinoma and postoperative adhesions in abdominal surgery are classified as disorders of adhesion and are the major causes of pain, infertility and death in women. Endometriosis is characterized by the presence of endometrial tissue in ectopic sites, outside the uterus and is associated with dysmenorrhea, pelvic pain and infertility. Although it is the most common gynecologic disorder, the etiology or pathogenesis of this disease is poorly understood. There are no experimental systems currently available to critically investigate the mechanisms of endometrial cell adhesion, mediation of immune mechanisms and the interactions of epithelial, stromal and immune cells with the peritoneal and ovarian cells leading the development of this disease. Preliminary studies using peritoneal fluids from individuals with and without endometriosis has enabled us to develop an experimental nude mouse model for ovarian sites. Funds are requested for establishing this in vivo model system which has potential usefulness not only in the study of the mechanisms involved in endometriosis but also in the study of chemotactic factors and the epithelial, stromal and lymphoid cell interactions. Development of this model system may have potential applications in other disorders of adhesions such as ovarian carcinomas and postsurgical adhesions in abdominal surgery.

子宫内膜异位症、卵巢癌与术后腹腔粘连 手术被归类为粘连疾病，是主要原因 妇女的疼痛、不孕和死亡。 子宫内膜异位症的特点 由于子宫内膜组织存在于异位部位（子宫外） 子宫，并与痛经、盆腔疼痛和不孕有关。 虽然它是最常见的妇科疾病，但其病因或 对这种疾病的发病机制知之甚少。 没有 目前可用于批判性研究的实验系统 子宫内膜细胞粘附机制、免疫机制介导 以及上皮细胞、基质细胞和免疫细胞与 腹膜和卵巢细胞导致这种疾病的发展。 使用患有以下疾病的个体的腹膜液进行的初步研究 没有子宫内膜异位症使我们能够开发实验性裸体 卵巢部位的小鼠模型。 需要资金来建立这个 体内模型系统不仅在研究中具有潜在的用途 子宫内膜异位症的机制以及研究 趋化因子和上皮细胞、基质细胞和淋巴细胞 互动。 该模型系统的开发可能具有潜力 在其他粘连疾病（如卵巢癌）中的应用 以及腹部手术中的术后粘连。