INTERNATIONAL CONFERENCE--PARVOVIRUS

这是一份申请支持国际会议的申请书 细小病毒。几乎所有的美国公民都感染了这股 两种类型的细小病毒导致成年；一种可以复制 在细胞培养中是自主的，第二种类型需要合并感染 与辅助腺病毒或疱疹病毒一起进行生产性感染。 前者是导致再生障碍性贫血危象的重要病原体 在患有溶血性贫血、传染性红斑的人中，某些形式的 关节炎和中期妊娠流产。后一种类型还没有 被牵连为任何疾病的原因，但会导致潜在的感染， 可能是在很高比例的人群中。感染该病毒 从属病毒与宫颈癌呈负相关。 这两种类型在模型系统中都是抗癌的，所以有相当的 一种自然有益的人类病毒的新可能性。这个 依赖病毒在特定的位置整合到人类基因组中 染色体L9(9)。已经产生了稳定集成的能力 对这些病毒用于基因治疗的浓厚兴趣。我们的 打算召开一次国际会议来讨论所有这些问题 问题。我们预计将有125-150人出席，代表来自 几乎所有活跃在该领域的实验室都位于 美国、加拿大、欧洲和亚洲。

This is an application for support for an International meeting on Parvovirus. Almost all US citizens have been infected by the tide of adulthood by two types of parvoviruses; one that can replicate autonomously in cell culture and a second type that requires coinfection with a helper adeno- or herpesvirus to undergo a productive infection. The former type is a significant pathogen responsible for aplastic crisis in people with hemolytic anemia, erythema infectiosum, some forms of arthritis, and second trimester abortions. The latter type has not been implicated as the cause of any disease but causes latent infections, possibly in a high percentage of people. Infection with the dependoviruses has been inversely correlated with carcinoma of the cervix. Both types are antioncogenic in model systems, so there is the rather novel possibility of a naturally beneficial human virus. The dependoviruses integrate into the human genome at a specific site on chromosome l9(9). The ability to integrate stably has engendered significant interest in the use of these viruses for gene therapy. Our intention is to have an international meeting to discuss all of these issues. We anticipate attendance of 125-150 with representation from almost all of the laboratories active in the field which are located in the US and Canada, Europe and Asia.