TB IN IV DRUG ABUSERS--A THREE-CITY STREET-BASED STUDY

静脉注射毒品滥用者中的结核病——基于三个城市街道的研究

• 批准号: 2121560
• 负责人: ALAN R LIFSON
• 金额: $ 32.01万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2121560
• 关键词: AIDS /HIV test; HIV infections; Mycobacterium tuberculosis; anergy; crack cocaine; ethnic group; fungal antigens; gender difference; health behavior; helper T lymphocyte; high risk behavior /lifestyle; human age group; human subject; immunosuppression; intravenous drug abuse; leukocyte count; longitudinal human study; mass screening; mumps virus; questionnaires; racial /ethnic difference; respiratory disorder epidemiology; tuberculin test; tuberculosis; virus antigen

This multi-site study will conduct for tuberculosis (TB) among out-of- treatment injection during users (IDUs) recruited from three communities in the western U.S.: The San Francisco Bay Area, Portland and Denver. Specific research objectives are to determine: (1) The prevalence of Mycobacterium tuberculosis infection by region, gender, race/ethnicity, age and HIV-infection status; (2) The incidence of the new M. tuberculosis infection, as indicated by tuberculin skin test conversions; (3) Behavioral and demographic correlates of TB infection, including homelessness, incarceration and drug use patterns; (4) The prevalence of skin test anergy among IDUs, by HIV-status and level of immune suppression (as reflected in DC4+ lymphocyte count); and (4) Behavioral correlates of skin test anergy. All three sites in this proposal are currently conducting community-based studies of IDUs which include interviews and HIV-antibody testing; studies for TB will be integrated with these existing projects. Over the course of this three-year study, we will perform tuberculin skin tests with purified protein derivative (PPD) on 1633 IDUs who meet our inclusion criteria; all PPD-negative IDUs will have this result confirmed by receiving a booster skin test one month later. One hundred fifty-seven HIV-infected IDUs and a random sample of 314 HIV-negative IDUs will be evaluated for skin test anergy using two standard controls (dermatophyton and mumps); CD4+ lymphocyte counts will be determined on all HIV-positive subjects. All PPD-positive subjects will be referred for chest X-rays and other medical evaluation to determine if active tuberculosis is present and (if not) whether preventive antituberculous therapy is indicated. All PPD-negative IDUs will receive another tuberculin skin test after six months to follow-up to look for new M. tuberculosis infections. PPD-negative subjects from San Francisco will receive additional screening for TB after twelve and eighteen months of follow-up. In addition to meeting the research objectives described above, this study will establish a model for TB testing of IDUs and other difficult-to-access populations in community- based settings.

这个多地点的研究将进行结核病（TB）的外