EPIDEMIOLOGY OF ORAL MANIFESTATIONS OF HIV INFECTION

HIV 感染口腔表现的流行病学

• 批准号: 3732502
• 负责人: ALAN R LIFSON
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3732502
• 关键词: AIDS; HIV infections; Herpesviridae disease; Kaposi's sarcoma; antiAIDS agent; aphthous stomatitis; bisexual; candidiasis; child (0-11); communicable disease diagnosis; congenital infection; dental disorder; dentistry; disease /disorder proneness /risk; epidemiology; female; gender difference; helper T lymphocyte; hemophilia As; homosexuals; human morbidity; human subject; intravenous drug abuse; opportunistic infections; oral leukoplakia; oral pharyngeal disorder; oral pharyngeal disorder diagnosis; prognosis; racial /ethnic difference; sex behavior; thrombocytopenic purpura; warts; zidovudine

The study of the oral manifestations of human immunodeficiency virus (HIV) infection offers unique and important opportunities to improve our knowledge of the epidemiology of AIDS and HIV. During the last five years, the Oral AIDS Center has developed a good understanding for certain risk groups (such as homosexual men) as to which oral lesions are associated with HIV infection, and their prognostic significance for the development of AIDS. During the next five years, we will answer these questions for other, less well studied populations such as women and racial/ethnic minorities. Building on our findings from the first five years, we will now more precisely determine where oral lesions fit in the overall pattern of progression from HIV infection to AIDS by evaluating three major areas: (1). The relationship between oral lesions and HIV infection (including time from infection to lesion), and the association between oral lesions and degree of immune suppression, as reflected in CD4+ count; (2). The prognostic significance of oral lesions for the development of AIDS, and for survival; (3). Whether certain factors (including sexual practices, drug use practices, and medical therapies such as zidovudine) increase or decrease the likelihood of developing specific lesions. We will also collaborate on clinical and molecular studies with the Clinical core and (through the Core) with Projects 2 and 3. The cohort studies will continue to be our primary source of data for these investigations, although we will also continue our collaboration with UCSF Stomatology Clinical Center/Oral AIDS Clinic and the UCSF Adult Immunodeficiency Clinic. The past five years have produced excellent descriptive and analytic studies concerning the oral manifestations of HIV. Our current and future research based on this knowledge will allow us to better define, for different populations, the relationship of oral lesions to the entire spectrum of HIV disease progression.

人类免疫缺陷病毒（HIV）口腔表现的研究 感染提供了独特和重要的机会，以改善我们的 艾滋病和艾滋病毒的流行病学知识。 在过去的五年里， 口腔艾滋病中心已经对某些风险有了很好的了解， 与口腔病变相关的人群（如同性恋男性） 与HIV感染，及其预后意义的发展， 艾滋病 在接下来的五年里，我们将回答这些问题， 其他研究较少的人群，如女性和种族/民族 少数群体 基于我们前五年的发现，我们将 现在可以更精确地确定口腔病变在整体模式中的位置 通过评估以下三个主要方面来评估从艾滋病毒感染到艾滋病的进展： （一）. 口腔病变与HIV感染（包括 从感染到病变的时间），以及口腔病变之间的关联 和免疫抑制程度，反映在CD 4+计数;（2）。 的 口腔病变对艾滋病发展的预后意义，以及 生存;（3）。 是否某些因素（包括性行为， 药物使用的做法，和药物治疗，如齐多夫定）增加或 降低发生特定病变的可能性。 我们还将 与临床核心合作进行临床和分子研究， （通过核心）与项目2和3。 队列研究将继续进行 作为这些调查的主要数据来源，尽管我们将 我们还继续与UCSF口腔临床中心/口腔 艾滋病诊所和UCSF成人免疫缺陷诊所。 在过去的五年里， 关于艾滋病毒口腔表现的研究。 我们当前和未来 基于这些知识的研究将使我们能够更好地定义， 不同的人群，口腔病变的关系， 艾滋病毒疾病进展谱。