ENVIRONMENTAL INFLUENCES AND DENTAL CARIES

龋齿的产生是由于地球上严重的生态失衡 齿面。显然，这些失衡是由环境压力造成的。 这包括但不限于，从糖和 重金属。微生物可以通过上调蛋白的表达来适应压力 几个基因和基因产物的生产。这种适应可能会增强 口腔微生物的毒性。底物的可用性可用于 克服产酸环境的压力，例如唾液肽， 可以帮助减少口腔微生物适应的需要，而且在 同时降低龋齿患病率。重金属， 尤其是铅，构成了主要的环境应激源之一， 尤其是在儿童中。铅无处不在，会影响牙齿 形成，唾液功能，也许还有微生物。该计划 这里提供的项目建议探索，在一个密切协调的 时尚，环境、压力源和龋齿的相互作用。 提供三个方案：1)唾液精氨酸/赖氨酸/多肽和 龋齿经验(Tabak、Billings和Moss博士)；2)适应 环境压力与龋齿(Marquis、Burne和 3)重金属(铅)对唾液腺的影响 功能与龋齿(鲍文、梅尔文和华生博士)。此外, 有一个行政核心(鲍文博士)和一个生物统计学核心(鲍文博士)。 劳伯塔斯)。所有的调查员都有丰富的盗窃经验 菲尔兹。该计划项目将与现有的龋齿研究相结合， 以及牙科研究部内部的培训补助金。忠告 委员会已经成立，其中包括四名外部顾问(Dr。 约瑟夫·费雷蒂、马克·赫兹伯格、欧文·曼德尔和杰森·坦泽) 审查了目前的提案，并将就研究进展提供建议， 评估，以及新的方法。尊敬的高级副院长保罗·拉塞勒博士， 罗切斯特大学，是拟任董事的特别顾问。 环境健康科学中心主任托马斯·克拉克森博士， 罗切斯特大学将担任顾问。产生的信息 来自该计划项目的信息将通过出版物和 在地方研讨会和国家会议上发表演讲。

Dental caries arises as a result of major ecological imbalances on the tooth surface. Clearly, these imbalances arise from environmental stresses which include, but are not limited to, acid production from sugars and heavy metals. Microorganisms can adapt to stress through up-regulation of several genes and production of gene products. This adaptation may enhance the virulence of oral microorganisms. The availability of substrates to overcome the stress of an acidogenic environment, e.g. salivary peptides, can help to reduce the need for adaptation by oral microorganisms, and at the same time reduce the prevalence of dental caries. Heavy metals, particularly lead, constitute one of the major environmental stressors, particularly in children. Lead is pervasive and can affect tooth formation, salivary function, and perhaps microorganisms. The Program Project offered here proposes to explore, in a closely coordinated fashion, the interaction of the environment, stressors, and dental caries. Three projects are offered: 1) Salivary Arginine/Lysine/Peptides and Caries Experience (Drs. Tabak, Billings, and Moss); 2) Adaptation to Environmental Stresses and Dental Caries (Drs. Marquis, Burne, and Quivey); 3) and Influence of Heavy Metals (Lead) on Salivary Gland Function and Dental Caries (Drs. Bowen, Melvin, and Watson). In addition, there is an Administrative Core (Dr. Bowen) and a Biostatistical Core (Dr. Raubertas). All of the investigators have extensive experience in theft fields. The Program Project will interface with existing caries research, and training grants within the Department of Dental Research. An Advisory Committee has been formed, which includes four external consultants (Drs. Joseph Ferretti, Mark Herzberg, Irwin Mandel, and Jason Tanzer) who reviewed the current proposals and will advise on research progress, evaluation, and new approaches. Dr. Paul La Celle, Senior Associate Dean, University of Rochester, is special consultant to the proposed director. Dr. Thomas Clarkson, Director of Environmental Health Sciences Center, University of Rochester, will serve as consultant. Information arising from the Program Project will be disseminated through publications and presentations at local seminars and national meetings.