ENVIRONMENTAL INFLUENCES AND DENTAL CARIES

龋齿的产生是由于主要的生态失衡， 齿面显然，这些不平衡源于环境压力 其包括但不限于从糖产生酸， 重金属微生物可以通过上调 几个基因和基因产物的生产。这种适应性可以增强 口腔微生物的毒性。基质的可用性， 克服产酸环境的应激，例如唾液肽， 可以帮助减少口腔微生物适应的需要， 同时减少龋齿的患病率。重金属， 特别是铅，构成了主要的环境压力源之一， 特别是在儿童中。铅是普遍存在的，会影响牙齿 形成，唾液功能，也许还有微生物。程序 这里提供的项目建议探索，在一个密切协调的 时尚，环境，压力源和龋齿的相互作用。 提供三个项目：1）唾液精氨酸/赖氨酸/肽和 龋齿经验（Tabak，Billings和Moss博士）; 2）适应 环境压力和龋齿（马奎斯博士，伯恩，和 重金属（铅）对唾液腺的影响 功能与龋齿（Bowen、Melvin和沃森博士）。此外，本发明还提供了一种方法， 有一个管理核心（Bowen博士）和一个生物统计核心（Bowen博士）。 Raubertas）。所有的调查人员都有丰富的盗窃经验 领域的该计划项目将与现有的龋齿研究， 和牙科研究部内的培训赠款。一个咨询 委员会已成立，其中包括四名外部顾问（博士。 约瑟夫·费雷蒂、马克·赫茨伯格、欧文·曼德尔和杰森·坦泽）， 检讨现时的建议，并会就研究进度提供意见， 评估和新方法。Paul La策勒博士，高级副院长， 罗切斯特大学的特别顾问，拟任主任。 托马斯克拉克森博士，环境健康科学中心主任， 罗切斯特大学，将担任顾问。产生的信息 将通过出版物传播， 在地方研讨会和国家会议上发言。

Dental caries arises as a result of major ecological imbalances on the tooth surface. Clearly, these imbalances arise from environmental stresses which include, but are not limited to, acid production from sugars and heavy metals. Microorganisms can adapt to stress through up-regulation of several genes and production of gene products. This adaptation may enhance the virulence of oral microorganisms. The availability of substrates to overcome the stress of an acidogenic environment, e.g. salivary peptides, can help to reduce the need for adaptation by oral microorganisms, and at the same time reduce the prevalence of dental caries. Heavy metals, particularly lead, constitute one of the major environmental stressors, particularly in children. Lead is pervasive and can affect tooth formation, salivary function, and perhaps microorganisms. The Program Project offered here proposes to explore, in a closely coordinated fashion, the interaction of the environment, stressors, and dental caries. Three projects are offered: 1) Salivary Arginine/Lysine/Peptides and Caries Experience (Drs. Tabak, Billings, and Moss); 2) Adaptation to Environmental Stresses and Dental Caries (Drs. Marquis, Burne, and Quivey); 3) and Influence of Heavy Metals (Lead) on Salivary Gland Function and Dental Caries (Drs. Bowen, Melvin, and Watson). In addition, there is an Administrative Core (Dr. Bowen) and a Biostatistical Core (Dr. Raubertas). All of the investigators have extensive experience in theft fields. The Program Project will interface with existing caries research, and training grants within the Department of Dental Research. An Advisory Committee has been formed, which includes four external consultants (Drs. Joseph Ferretti, Mark Herzberg, Irwin Mandel, and Jason Tanzer) who reviewed the current proposals and will advise on research progress, evaluation, and new approaches. Dr. Paul La Celle, Senior Associate Dean, University of Rochester, is special consultant to the proposed director. Dr. Thomas Clarkson, Director of Environmental Health Sciences Center, University of Rochester, will serve as consultant. Information arising from the Program Project will be disseminated through publications and presentations at local seminars and national meetings.