BRAIN PEPTIDES IN PITUITARY FUNCTIONS AND DIABETES

脑肽在垂体功能和糖尿病中的作用

• 批准号: 2137230
• 负责人: ANDREW BAIRD
• 金额: $ 51.3万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-01 至 1996-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2137230
• 关键词: fibroblast growth factor

This proposal is a continuation of a program project that, over the course of the last sixteen years, has dealt with problems in fundamental and applied neuroendocrinology as they apply to the fields of diabetes, pituitary and brain function and the biology of cell proliferation. The long-term objectives are to understand the role played by key proteins in the onset and progression of diabetes and its complications. It is proposed (1) to establish how angiogenic factors are regulated and identify the mechanisms which promote and/or limit their bioavailability; (2) to determine how dysfunction of these regulatory elements in disorders such as diabetes might mediate microvascular complications; (3) to characterize novel growth inhibitors and use these molecules to study diseases of cell proliferation; (4) to study the molecular biology of fibroblast growth factor; (5) its receptor; and (6) the regulation of their expression. These specific aims are to be supported by the presence of state-of-the-art cores of immunotechniques, nucleotide synthesis, peptide synthesis and sequencing, which serve on one hand as the backbone uniting a comprehensive research program in diabetes, pituitary, and growth factor biology and on the other as the necessary resource to develop and import novel and/or improved techniques and technology to the research projects to ensure that the program remains at the forefront of science.

该提案是一个项目的延续，在整个过程中， 在过去的16年里，他处理了一些基本问题， 应用神经内分泌学，因为它们适用于糖尿病领域， 垂体和脑功能以及细胞增殖的生物学。 的 长期目标是了解关键蛋白质在 糖尿病及其并发症的发生和发展。 是 建议（1）建立血管生成因子是如何调节和识别 促进和/或限制其生物利用度的机制;（2） 确定这些调节元件的功能障碍是如何在疾病中， 糖尿病可能介导微血管并发症;（3）表征 新的生长抑制剂，并使用这些分子来研究细胞疾病 研究成纤维细胞生长的分子生物学 因子;（5）其受体;和（6）其表达的调节。 这些具体目标将得到最先进技术的支持。 免疫技术的核心，核苷酸合成，肽合成和 排序，一方面作为骨干， 糖尿病、脑垂体和生长因子生物学研究项目， 另一种是开发和进口新的和/或 改进技术和技术的研究项目，以确保 该计划仍然处于科学的前沿。