CLINICAL MEASURES OF AUDITORY LINEAR/NONLINEAR PROCESSES

听觉线性/非线性过程的临床测量

• 批准号: 2127244
• 负责人: MARK E CHERTOFF
• 金额: $ 10.47万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2127244
• 关键词: aspirin; audiometry; auditory threshold; cochlear microphonic potentials; guinea pigs; human subject; noise; ototoxin; psychoacoustics; sensorineural hearing loss; speech recognition

A common finding in clinical audiology is that hearing-impaired listeners with similar configurations and degrees of hearing loss perform differently on measures of speech perception. Consequently, these people may differ in the benefits they receive from amplification. One reason for the lack of homogeneity among hearing-impaired listener is that the audiogram provides only a rough estimate of cochlear pathology. Thus, it is possible that hearing-impaired listeners differ in their underlying cochlear pathology and measures of pure-tone threshold lack the sensitivity to distinguish these individuals. Cochlear pathology alters cochlear transduction processes. Mechano- electric and electro-mechanic transduction processes are modified, either directly through changes in hair cell structure, or indirectly, through structures on which hair cell transduction relies. An objective measure that characterizes these processes will describe the physiologic consequences of cochlear disorders and supply a more accurate description of sensorineural hearing loss then presently available. A clinical measure of cochlear transduction could lead to a new categorization scheme of sensorineural hearing loss based on the underlying pathophysiology. The long term goal of this research is to use such a scheme to determine if the underlying physiologic changes in the cochlea can account for the variation between hearing-impaired listeners on functional measures of hearing, and design new signal processing algorithms for hearing aids. Cochlear transduction processes are inherently nonlinear, therefore, a measure of cochlear transduction must be sensitive to nonlinear processes. Auditory distortion products are indices of nonlinearity and reflect cochlear integrity, but their absence only indicates a change in transduction, not a description of the altered transduction processes. A new nonlinear systems identification procedure developed by Bendat (1990) can be used to characterize cochlear transduction processes across a broad range of frequencies. This technique can be applied to ECochG, AEPs, and OAEs, thus, both mechano-electric and electro-mechanic transduction processes in the cochlea can be described. The special goal of this investigation is to use Bendat's procedure to develop a measure of cochlear transduction, quantify the reliability of the measure, and determine its sensitivity to changes in cochlear physiology due to cochlear damage.

临床听力学的一个普遍发现是听力受损的听众 具有相似的配置和听力损失程度 对语音感知的度量有所不同。 因此，这些人 他们从放大中获得的好处可能有所不同。 一个原因 因为听力受损的听众缺乏同质性是 听力图仅提供了对耳蜗病理学的粗略估计。 因此，它 听力受损的听众可能在其基础上有所不同 人工耳蜗病理学和纯色阈值的度量缺乏 敏感性区分这些人。 人工耳蜗病理改变了人工耳蜗转导过程。 机械 电力和电力转导过程要么修改 直接通过毛细胞结构的变化，或间接地通过 毛细胞转导依赖的结构。 客观的措施 这些过程的特征将描述生理 耳蜗疾病的后果并提供了更准确的描述 当前可用的感官听力损失。 临床 人工耳蜗转导的度量可能导致新的分类方案 基于潜在的病理生理学的感官听力损失。 这项研究的长期目标是使用这样的方案来确定 如果耳蜗的基本生理变化可以解释 听力受损的听众在功能度量方面的差异 听力并设计了助听器的新信号处理算法。 因此，耳蜗转导过程本质上是非线性的，因此 耳蜗转导的度量必须对非线性过程敏感。 听觉失真产品是非线性指数，反映 人工耳蜗完整性，但他们的缺席仅表示改变 转导，而不是对改变转导过程的描述。 一个 Bendat（1990）开发的新的非线性系统识别程序 可以用来表征广泛的人工耳蜗转导过程 频率范围。 该技术可以应用于Ecochg，AEPS和 OAE，因此，机械电力和电力转导 可以描述耳蜗中的过程。 这个特殊目标 调查是使用Bendat的程序来制定 人工耳蜗转导，量化措施的可靠性，以及 确定其对由于 人工耳蜗损坏。