Automated Objective Audiometry using Long Latency Steady State Responses

使用长延迟稳态响应的自动客观测听

• 批准号: 9344929
• 负责人: Rafael E Delgado
• 金额: $ 50.83万
• 依托单位: INTELLIGENT HEARING SYSTEMS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9344929
• 关键词: Address; Adult; Affect; Age; Algorithmic Analysis; Algorithms; Arousal; Assessment tool; Attention; Audiology; Audiometry; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory Threshold; Auditory system; Behavioral; Biological Assay; Buffers; Characteristics; Child; Clinic; Clinical; Cochlear Implants; Comb animal structure; Communication; Comprehension; Conductive hearing loss; Data; Data Analyses; Data Reporting; Data Set; Data Storage and Retrieval; Detection; Development; Devices; Discrimination; Disease; Ear; Evaluation; Frequencies; Goals; Hearing; Hearing Tests; Infant; Legal patent; Longevity; Measurement; Methods; Neuropathy; Newborn Infant; Noise; Outcome; Participant; Patients; Phase; Protocols documentation; Publications; Research Personnel; Resolution; Response Latencies; Risk; Signal Transduction; Speech; Statistical Data Interpretation; Stimulus; Stroke; System; Techniques; Testing; Time; Work; auditory pathway; base; clinical application; clinical practice; computerized tools; cost; data acquisition; efficacy testing; experimental study; hearing screening; improved; instrument; relating to nervous system; response; slow potential; software systems; statistics; success; symposium; tool

The aim of this project is to develop an automated hearing threshold estimation system using cortical auditory long-latency evoked responses (LLR) analyzed objectively in a steady-state condition. Test methods that dominate clinical practice today, such as auditory brainstem response (ABR) and auditory steady state response (ASSR), permit only indirect inferences about hearing sensitivity and cannot provide a comprehensive view of the auditory pathway, as can be achieved with cortical responses. Previously, maturation and level-of-arousal issues, as well as lack of comfort by clinical audiologists in the interpretation of LLR results have limited their widespread clinical implementation. The investigators have demonstrated in their previous work and in a number of recent publications that an objective analysis approach can be successfully applied to the LLR – defined as the Auditory Steady State Long Latency Responses (ASSLLR) -- using modulation rates below 20 Hz. The work to date has demonstrated success in adults, children and infants with a planned focus for this application on this youngest group, as they cannot be tested by conventional audiometry and because they present the greatest challenges for cortical responses. The specific aims of this Phase II project are, as follows: 1) Optimization of the ASSLLR acquisition system to improve data and spectral analysis resolution and incorporation of response analysis and detection algorithms onto the system platform currently manufactured and marketed by Intelligent Hearing Systems, 2) Refinement of algorithm and analysis tools for response detection and noise reduction, 3) Evaluation of the system for data acquisition in subjects with normal hearing (n=20) and in children and adults with known sensorineural and conductive hearing losses (n=50) compared to behavioral thresholds, 4) Evaluation of the system for data acquisition and analysis in newborns and young infants (n=80) compared to ABR with special attention to participant state. Work will also involve development of test protocols and reference datasets based on the outcomes of Specific Aims 3 & 4 and demonstration that responses can be acquired with supra-threshold speech stimuli as well. The successful completion of this work will result in a clinical tool that will provide methods for objective evaluation of the auditory system that includes the cortical level.

该项目的目的是开发一种使用皮质的自动听力阈值估计系统 在稳态条件下客观分析听觉长潜伏期诱发反应（LLR）。测试 当今临床实践中占主导地位的方法，例如听觉脑干反应（ABR）和 听觉稳态响应（ASSR），仅允许间接推断听力灵敏度和 无法提供听觉通路的全面视图，而皮层可以实现这一点 回应。以前，成熟度和唤醒水平问题以及临床缺乏安慰 听力学家对 LLR 结果的解释限制了其广泛的临床实施。 研究人员在他们之前的工作和最近的一些出版物中证明了 客观分析方法可以成功应用于 LLR（定义为听觉） 稳态长延迟响应 (ASSLLR)——使用低于 20 Hz 的调制速率。该工作至 date 已在成人、儿童和婴儿中取得成功，并计划重点关注这一点 应用于这个最年轻的群体，因为他们无法通过传统的听力测试进行测试 因为它们对皮质反应提出了最大的挑战。本阶段的具体目标 二、项目内容如下： 1）优化ASSLLR采集系统，提高数据和 光谱分析分辨率以及响应分析和检测算法的结合 目前由Intelligent Hearing Systems制造和销售的系统平台，2) 完善 用于响应检测和降噪的算法和分析工具，3）评估 用于听力正常的受试者（n = 20）以及患有听力障碍的儿童和成人的数据采集系统 与行为阈值相比，已知的感音神经性和传导性听力损失 (n=50)，4) 新生儿和小婴儿数据采集和分析系统的评估（n=80） 与 ABR 相比，特别关注参与者状态。工作还将涉及测试的开发 基于具体目标 3 和 4 以及演示的结果的协议和参考数据集 也可以通过超阈值言语刺激来获得反应。成功者 这项工作的完成将产生一个临床工具，该工具将为客观评估提供方法 听觉系统，包括皮质层。