SPEECH AND FACIAL DEVELOPMENT AFTER PALATAL SURGERY
腭手术后的言语和面部发育
基本信息
- 批准号:2131341
- 负责人:
- 金额:$ 25.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1994
- 资助国家:美国
- 起止时间:1994-09-30 至 1999-09-29
- 项目状态:已结题
- 来源:
- 关键词:Brazil age difference audiometry child physical development cleft lip cleft palate cleft palate prosthesis cooperative study face human subject infant human (0-1 year) longitudinal human study postoperative complications postoperative state preoperative state preschool child (1-5) psychological adaptation socioeconomics speech statistics /biometry surgery
项目摘要
DESCRIPTION: This is the second revision of an application which was
originally submitted in response to a RFA. The present application is
for a collaborative study between the University of Florida Craniofacial
Center and the University of Sao Paulo, Hospital for Research and
Rehabilitation of patients with Cleft Lip and Palate, in Brazil. As in
the previous submission, a five year, prospective randomized controlled
study clinical trial (RCT) is proposed to compare velopharyngeal function
for speech outcomes of palatoplasty for complete unilateral cleft lip and
palate, performed with the von Langenbeck procedure with intravelar
velar plasty and the Furlow double opposing z-plasty palatoplasty. The
von Langenbeck procedure is considered to be the standard against which
the "relatively new" Furlow procedure will be compared. The Furlow
procedure has been reported to have a higher rate of velopharyngeal
competency and hence improved speech results and also should result in
less disturbance to mid-facial growth. The clinical caseload at the
Hospital for Research and Rehabilitation of patients with Cleft Lip and
Palate, located in Bauru, is 1,200 new patients per year. It is
anticipated that the entire study group of 608 patients can be entered
within the first two years of the study. A 2x2x2 factorial design is
described involving type of lip repair (Spina versus Milard), age at
surgery (9-12 months versus 15-18 months) and type of palate repair (von
Langenbeck versus Furlow). A fixed length, blocked randomization
algorithm, which will be stratified by surgeon, will be used to allocate
participants equally among the eight cells of the factorial
design.Patients will be recruited over a 21 month period. An extensive
data base will be assembled from pre-operative assessments and post-
operative visits scheduled every six months post-surgery. Study data
will be transmitted electronically to facilities at the University of
Florida for data management, editing and statistical analysis. Besides
the primary comparison of the two palatoplasty procedures, the applicant
plans to assess the impact of age at surgery on post-operative
velopharyngeal competency for speech, impact of age at surgery on the
severity of articulatory errors, impact of type of palatal surgery on
severity of articulatory errors, impact of age at surgery and type of
palatal surgery on post-operative otologic and audiologic status,
relationship between family socioeconomic status and velopharyngeal
competency and articulatory proficiency, relationship between family
adaption and post-operative speech outcome and impact of surgical
technique and age at surgery on the frequency of post-operative
complications.
描述:这是申请的第二次修订
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM N WILLIAMS其他文献
WILLIAM N WILLIAMS的其他文献
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{{ truncateString('WILLIAM N WILLIAMS', 18)}}的其他基金
Facial and Dental Arch Growth Following Palatal Surgery
腭手术后面部和牙弓的生长
- 批准号:
6949719 - 财政年份:2004
- 资助金额:
$ 25.08万 - 项目类别:
Facial and Dental Arch Growth Following Palatal Surgery
腭手术后面部和牙弓的生长
- 批准号:
7073454 - 财政年份:2004
- 资助金额:
$ 25.08万 - 项目类别:
Facial and Dental Arch Growth Following Palatal Surgery
腭手术后面部和牙弓的生长
- 批准号:
7247949 - 财政年份:2004
- 资助金额:
$ 25.08万 - 项目类别:
Facial and Dental Arch Growth Following Palatal Surgery
腭手术后面部和牙弓的生长
- 批准号:
7460869 - 财政年份:2004
- 资助金额:
$ 25.08万 - 项目类别:
Facial and Dental Arch Growth Following Palatal Surgery
腭手术后面部和牙弓的生长
- 批准号:
6807594 - 财政年份:2004
- 资助金额:
$ 25.08万 - 项目类别:
LIP PRESSURE AFTER MILLARD AND SPINA CLEFT LIP SURGERY
米勒德和脊柱裂唇手术后的唇压
- 批准号:
2796477 - 财政年份:1997
- 资助金额:
$ 25.08万 - 项目类别:
VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
腭手术后的腭咽功能
- 批准号:
2867011 - 财政年份:1994
- 资助金额:
$ 25.08万 - 项目类别:
VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
腭手术后的腭咽功能
- 批准号:
2796462 - 财政年份:1994
- 资助金额:
$ 25.08万 - 项目类别:
VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
腭手术后的腭咽功能
- 批准号:
6760178 - 财政年份:1994
- 资助金额:
$ 25.08万 - 项目类别:
VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
腭手术后的腭咽功能
- 批准号:
2545658 - 财政年份:1994
- 资助金额:
$ 25.08万 - 项目类别:
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