Facial and Dental Arch Growth Following Palatal Surgery

腭手术后面部和牙弓的生长

• 批准号: 7247949
• 负责人: WILLIAM N WILLIAMS
• 金额: $ 37.41万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7247949
• 关键词: Academic Medical Centers; Adherence; Adult; Affect; Age; Age-Months; Age-Years; Brazil; Budgets; Caring; Child; Cleaved cell; Cleft Lip; Cleft Palate; Clinical Trials; Closure; Collaborations; Congenital Abnormality; Data; Deformity; Dental arch structure; Early Diagnosis; Enrollment; Esthetics; Face; Family health status; Fistula; Florida; Follow-Up Studies; Goals; Growth; Hospitals; Incidence; Individual; Jaw; Lighting; Lip structure; Longitudinal Studies; Maxilla; Measures; Medical; Millard technique; Nose; Operative Surgical Procedures; Orthodontics; Outcome Measure; Palate; Parents; Patient Selection; Patients; Planet Mars; Principal Investigator; Procedures; Progress Reports; Randomized; Rehabilitation therapy; Relative (related person); Research Design; Research Personnel; Savings; Skeletal system; Speech; Subgroup; Surgeon; Syndrome; Techniques; Time; Universities; Variant; age group; cleft lip and palate; cost; craniofacial; experience; follow-up; infancy; malformation; motor disorder; oral motor; orthognathic; palatal surgery; palate repair; programs; prospective; repaired; self esteem; soft tissue

DESCRIPTION: The incidence of cleft lip/palate is approximately 1/750, making it one of the most common congenital malformations. The primary goal in surgically repairing the palatal cleft is to construct a velopharyngeal port capable of supporting normal non-nasal speech without impairing growth of the face or Dental arches. Adults with unrepaired cleft lip and palate rarely have the recessed midface that too often characterizes the profile of adults whose cleft lip and palate have been repaired in infancy. Factors associated with the surgery are likely the major cause of midface growth disturbance. The University of Florida, in collaboration with the University of Sao Paulo, Bauru, Brazil, is proposing a longitudinal study to determine whether children between 6 and 10 years of age, born with complete unilateral cleft lip and palate, have different facial and/or Dental arch relationships as a function of the surgical techniques used in repairing their lip and/or palate, and/or as a function of their age when they received palatal surgery. This study proposes to enroll the entire patient pool of 475 patients who currently are subjects in an ongoing NIDCR sponsored study in which speech and velopharyngeal outcome measures are being assessed relative to the surgical techniques subjects underwent. Subjects were randomly assigned for lip surgery (Spina vs. Millard technique), palatal surgery (von Langenbeck vs. Furlow procedure), and age of palatal repair (9-12 months vs. 15-18 months). The proposed study will provide data defining the maxillary growth and Dental arch relationships in this very large group of patients, from which conclusions should be possible regarding the relative importance of the Millard or Spina lip repair and the von Langenbeck palatoplasty or the double opposing z-plasty palate repair on facial and Dental arch growth. A secondary part of the study will be a long-term follow-up of velopharyngeal function for speech.

描述：唇腭裂的发病率约为1/750，是最常见的先天性畸形之一。手术修复腭裂的主要目的是建立一个能够支持正常非鼻音语音而不损害面部或牙弓生长的腭咽通道。未修复唇腭裂的成年人很少有凹陷的面中部，这通常是在婴儿期修复唇腭裂的成年人的特征。与手术相关的因素可能是面中部生长障碍的主要原因。佛罗里达大学与巴西包鲁的圣保罗大学合作，提出了一项纵向研究，以确定6至10岁的儿童，出生时患有完全单侧唇腭裂，是否有不同的面部和/或牙弓关系，作为修复唇和/或腭的手术技术的函数，和/或作为他们接受腭部手术时的年龄的函数。本研究拟入组475例患者的整个患者库，这些患者目前是正在进行的NIDCR申办的研究的受试者，在该研究中，正在评估与受试者接受的手术技术相关的语音和咽喉结局指标。受试者被随机分配接受唇部手术（Spina vs. Millard技术）、腭部手术（von Langenbeck vs. Furlow手术）和腭部修复年龄（9-12个月vs. 15-18个月）。拟议的研究将提供定义这一非常大的患者群体中上颌骨生长和牙弓关系的数据，从中可以得出关于Millard或Spina唇修复和von Langenbeck腭成形术或双对向Z形腭成形术修复对面部和牙弓生长的相对重要性的结论。该研究的第二部分将是长期随访患者的语言功能。