Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance

增强乙二醛酶-1 的活性以增加二羰基清除率

• 批准号: DP200101965
• 负责人: Prof Merlin Thomas
• 金额: $ 42.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101965
• 关键词: Augmenting; activity; glyoxalase; increase; dicarbonyl

Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epigenetics and structural biology. It is expected that this work will improve understanding of this fundamental biological defence. This will allow us to identify the potential means to enhance the capacity of glyoxalase-1 to the future benefit of biological ageing.

新陈代谢过程中产生的活性中间体会导致衰老。乙二醛酶-1是对抗这些有毒中间体的关键防御酶，因此也会老化。本项目旨在探索乙二醛酶-1的表达和活性是如何被调控的新途径。这个跨学科的项目希望通过结合相关的细胞和动物模型、蛋白质化学、表观遗传学和结构生物学来产生新的认识。预计这项工作将提高对这种基本生物防御的理解。这将使我们能够确定提高乙二醛酶-1能力的潜在手段，以实现生物衰老的未来利益。