NEUROPEPTIDE CGRP AND VASCULAR RESPONSE TO SEPSIS
NEUROPEPTIDE CGRP AND VASCULAR RESPONSE TO SEPSIS
批准号:
2210773
负责人:
WARWICK A ARDEN
金额:
$7.93万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-08-01 至 1996-07-31
关键词:
aorta bacterial polysaccharides calcitonin gene related peptide capsaicin cyclic AMP cyclic GMP disease /disorder model endotoxins enzyme activity inhibitor /antagonist laboratory rat microcirculation neuropeptides nitric oxide phosphodiesterase inhibitors radioimmunoassay tissue /cell culture vascular endothelium vascular resistance vascular smooth muscle
中文摘要
该建议的基本假设是降钙素基因相关
英文摘要
The basic hypothesis of this proposal is that Calcitonin Gene Related
Peptide (CGRP) is an important mediator of vascular deregulation during
the latter stages of septic shock. Moreover the effect of substances
such as CGRP which rely, at least in part, on vascular smooth muscle
cyclic adenosine monophosphate (cAMP) generation as a mechanism of
action, show enhanced potency in the face of increased nitric oxide (NO)
production due to a specific interaction between the vascular cGMP and
cAMP systems. The studies described in this proposal are designed to;
1) further define the intracellular mechanisms of action of CGRP on
vascular smooth muscle and, specifically, to define the interactions
between CGRP and another mediator known to impact on vascular function
during septic shock, NO and 2) to establish if a cause and effect
relationship exists between augmented perivascular CGRP release during
septic shock, and progressive vascular dysfunction.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CGRP, NO, AND SEPSIS INDUCED MICROVASCULAR DYSFUNCTION
-
批准号:2024289
-
项目类别:
-
资助金额:$12.57万
-
财政年份:1997
-
负责人:WARWICK A ARDEN
-
依托单位:
CGRP, NO, AND SEPSIS INDUCED MICROVASCULAR DYSFUNCTION
-
批准号:6181158
-
项目类别:
-
资助金额:$9.95万
-
财政年份:1997
-
负责人:WARWICK A ARDEN
-
依托单位:
CGRP, NO, AND SEPSIS INDUCED MICROVASCULAR DYSFUNCTION
-
批准号:6525346
-
项目类别:
-
资助金额:$8.87万
-
财政年份:1997
-
负责人:WARWICK A ARDEN
-
依托单位:
CGRP, NO, AND SEPSIS INDUCED MICROVASCULAR DYSFUNCTION
-
批准号:2796778
-
项目类别:
-
资助金额:$9.11万
-
财政年份:1997
-
负责人:WARWICK A ARDEN
-
依托单位:
CGRP, NO, AND SEPSIS INDUCED MICROVASCULAR DYSFUNCTION
-
批准号:6019277
-
项目类别:
-
资助金额:$9.56万
-
财政年份:1997
-
负责人:WARWICK A ARDEN
-
依托单位:
ROLE OF NEUROPEPTIDE CGRP IN VASCULAR RESPONSE TO SEPSIS
-
批准号:3083328
-
项目类别:
-
资助金额:$7.98万
-
财政年份:1993
-
负责人:WARWICK A ARDEN
-
依托单位:
NEUROPEPTIDE CGRP AND VASCULAR RESPONSE TO SEPSIS
-
批准号:2210774
-
项目类别:
-
资助金额:$7.98万
-
财政年份:1993
-
负责人:WARWICK A ARDEN
-
依托单位:
SMALL VOLUME HYPERTONIC SALINE FOR INITIAL TREATMENT OF EQUINE ENDOTOXIC SHOCK
-
批准号:3891442
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WARWICK A ARDEN
-
依托单位:
IRON CHELATION IN PROTECTION OF EQUINE JEJUNUM FROM ISCHEMIA REPERFUSION INJURY
-
批准号:3954678
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WARWICK A ARDEN
-
依托单位:
IRON CHELATION IN PROTECTION OF EQUINE JEJUNUM FROM ISCHEMIA REPERFUSION INJURY
-
批准号:3931979
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WARWICK A ARDEN
-
依托单位:
海外基金