PREVALENCE OF RENOVASCULAR DISEASE IN THE ELDERLY

老年人血管疾病的患病率

• 批准号: 2146984
• 负责人: KIMBERLEY J HANSEN
• 金额: $ 18.7万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2146984
• 关键词: artery stenosis; coronary disorder; epidemiology; human old age (65+); human subject; kidney circulation; kidney function; longitudinal human study; medical complication; noninvasive diagnosis; renal artery obstruction; renal hypertension; renal ischemia /hypoxia; stroke; ultrasound blood flow measurement

Critical renovascular disease (RVD) in the elderly may contribute to renal insufficiency by causing renal ischemia. Additionally, the hypertension associated with critical RVD may increase the risk of coronary heart disease (CHD) and stroke. However, the actual contribution of critical RVD (defined as greater than 60% diameter- reducing renal artery stenosis or occlusion) to these important health issues is uncertain because the prevalence of RVD in the elderly is unknown. Meaningful prevalence estimates have been limited by the absence of suitable screening methods for critical RVD and by the absence of accurate data obtained in population-based cohort. Specifically, this project proposes the use of renal duplex sonography (RDS) to detect the presence of critical RVD. This non-invasive ultrasound technique allows rapid and accurate evaluation of critical RVD. RDS will be applied to the Forsyth County, North Carolina cohort from the ongoing NHLBI- sponsored Cardiovascular Health Study (CHS), a longitudinal population- based study of CHD and stroke in elderly men and women. As a four year ancillary proposal to CHS, the prevalence of critical RVD and its association with renal function, subclinical cardiovascular disease (i.e., carotid ultrasonography, echocardiography), CHD and stroke will be characterized during the first two years of the project. In the last two years, the incidence of CHD, stroke and subclinical cardiovascular disease in the CHS participants demonstration critical RVD, with and without renal insufficiency, will be characterized. The application of RDS to the CHS Forsyth County cohort provides a unique opportunity to estimate the true prevalence of critical RVD in this elderly population. RDS results in combination with demographic data and analytic measurements made as part of the CHS will achieve the specific aims of this project without the need for additional evaluation. As a result, unique information pertaining to important health issues in the elderly will be obtained in a cost-efficient manner. This information will provide rationale for further investigation to examine new strategies or medical and interventional management of critical RVD in the elderly.

老年重症肾血管疾病（RVD）可能导致 肾功能不全的原因是什么？ 另夕h 与危重RVD相关的高血压可能会增加 冠心病和中风。 但实际 临界RVD的贡献（定义为大于60%直径- 减少肾动脉狭窄或闭塞）对这些重要的健康 问题是不确定的，因为RVD在老年人中的患病率是 未知 有意义的流行率估计受到以下因素的限制 缺乏适当的筛选方法来筛选关键的RVD， 在基于人群的队列中获得的准确数据。 具体来说， 该项目建议使用肾脏双重超声检查（RDS）来检测 存在临界RVD。 这种非侵入性的超声波技术 快速准确地评估关键RVD。 RDS将应用于 福赛斯县，北卡罗来纳州队列从正在进行的NHLBI- 申办的心血管健康研究（CHS），纵向人群- 老年男性和女性冠心病和中风的基础研究。 作为一个四年 社区卫生服务的辅助建议，严重的风湿性关节炎的患病率及其 与肾功能、亚临床心血管疾病相关 (i.e.,颈动脉超声检查，超声心动图），冠心病和中风将 在项目的前两年进行评估。 在过去 两年间，冠心病、脑卒中和亚临床心血管疾病的发病率 CHS参与者中的疾病表现出严重的RVD， 没有肾功能不全，将被表征。 的应用 RDS到CHS福赛斯县队列提供了一个独特的机会， 估计该老年人群中严重RVD的真实患病率。 RDS结果结合人口统计数据和分析 作为CHS的一部分进行的测量将实现以下具体目标： 这个项目不需要额外的评估。 因此，在本发明中， 关于老年人重要健康问题的独特信息 将以具有成本效益的方式获得。 这些信息将 提供进一步调查的理由，以检查新的策略，或 老年人危重RVD的医疗和介入管理。