PREVALENCE OF RENOVASCULAR DISEASE IN THE ELDERLY

老年人血管疾病的患病率

• 批准号: 2458826
• 负责人: KIMBERLEY J HANSEN
• 金额: $ 4.89万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458826
• 关键词: artery stenosis; coronary disorder; epidemiology; human old age (65+); human subject; kidney circulation; kidney function; longitudinal human study; medical complication; noninvasive diagnosis; renal artery obstruction; renal hypertension; renal ischemia /hypoxia; stroke; ultrasound blood flow measurement

Critical renovascular disease (RVD) in the elderly may contribute to renal insufficiency by causing renal ischemia. Additionally, the hypertension associated with critical RVD may increase the risk of coronary heart disease (CHD) and stroke. However, the actual contribution of critical RVD (defined as greater than 60% diameter- reducing renal artery stenosis or occlusion) to these important health issues is uncertain because the prevalence of RVD in the elderly is unknown. Meaningful prevalence estimates have been limited by the absence of suitable screening methods for critical RVD and by the absence of accurate data obtained in population-based cohort. Specifically, this project proposes the use of renal duplex sonography (RDS) to detect the presence of critical RVD. This non-invasive ultrasound technique allows rapid and accurate evaluation of critical RVD. RDS will be applied to the Forsyth County, North Carolina cohort from the ongoing NHLBI- sponsored Cardiovascular Health Study (CHS), a longitudinal population- based study of CHD and stroke in elderly men and women. As a four year ancillary proposal to CHS, the prevalence of critical RVD and its association with renal function, subclinical cardiovascular disease (i.e., carotid ultrasonography, echocardiography), CHD and stroke will be characterized during the first two years of the project. In the last two years, the incidence of CHD, stroke and subclinical cardiovascular disease in the CHS participants demonstration critical RVD, with and without renal insufficiency, will be characterized. The application of RDS to the CHS Forsyth County cohort provides a unique opportunity to estimate the true prevalence of critical RVD in this elderly population. RDS results in combination with demographic data and analytic measurements made as part of the CHS will achieve the specific aims of this project without the need for additional evaluation. As a result, unique information pertaining to important health issues in the elderly will be obtained in a cost-efficient manner. This information will provide rationale for further investigation to examine new strategies or medical and interventional management of critical RVD in the elderly.

老年人的严重肾血管疾病（RVD）可能会导致 肾功能不全引起肾缺血。 此外， 与严重 RVD 相关的高血压可能会增加以下风险： 冠心病（CHD）和中风。 然而，实际情况 临界 RVD 的贡献（定义为大于 60% 直径- 减少肾动脉狭窄或闭塞）对这些重要的健康 问题尚不确定，因为老年人中 RVD 的患病率是 未知。 有意义的患病率估计受到以下因素的限制： 缺乏针对关键 RVD 的合适筛查方法，并且缺乏 在基于人群的队列中获得的准确数据。 具体来说，这 项目建议使用肾双功超声检查（RDS）来检测 存在严重的 RVD。 这种非侵入性超声技术允许 快速准确地评估关键 RVD。 RDS将应用于 来自正在进行的 NHLBI 的北卡罗来纳州福赛斯县队列 赞助的心血管健康研究（CHS），一项纵向人群- 老年男性和女性冠心病和中风的基础研究。 作为四年 对 CHS 的补充建议、严重 RVD 的患病率及其 与肾功能、亚临床心血管疾病的关系 （即颈动脉超声检查、超声心动图）、CHD 和中风将 在项目的头两年内进行表征。 在最后 两年来，冠心病、脑卒中和亚临床心血管疾病的发生率 CHS 参与者中的疾病表现出严重的 RVD，并且 无肾功能不全者，将为其特征。 应用 RDS 为 CHS 福赛斯县队列提供了一个独特的机会 估计该老年人群中危重 RVD 的真实患病率。 RDS 结果与人口统计数据和分析相结合 作为 CHS 一部分进行的测量将实现以下具体目标 该项目无需额外评估。 因此， 有关老年人重要健康问题的独特信息 将以具有成本效益的方式获得。 该信息将 为进一步调查以检查新策略或 老年人危重 RVD 的医疗和介入治疗。

项目成果

Associations between renovascular disease and prevalent cardiovascular disease in the elderly: a population-based study.

• DOI: 10.1177/153857440403800103
• 发表时间: 2004-01-01
• 期刊: Vascular and endovascular surgery
• 影响因子: 0.9
• 作者: Edwards, Matthew S;Hansen, Kimberley J;Dean, Richard H
• 通讯作者: Dean, Richard H

Associations between renal duplex parameters and adverse cardiovascular events in the elderly: a prospective cohort study.

• DOI: 10.1053/j.ajkd.2009.10.044
• 发表时间: 2010-02
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Pearce JD;Craven TE;Edwards MS;Corriere MA;Crutchley TA;Fleming SH;Hansen KJ
• 通讯作者: Hansen KJ