NEURAL EFFECTS OF LOW LEVEL MICROWAVES

申请人提出实验以进一步研究神经系统的功能。 低强度微波神经效应的机制 辐射在大鼠体内。 在之前的研究中，申请人发现， 急性低强度微波暴露改变了胆碱能神经元的活性， 在反复暴露后， 毒蕈碱胆碱能受体 此外，申请人发现， 这种作用是由内源性阿片类药物和促肾上腺皮质激素介导的， 释放因子（CRF）在大脑中。 为了进一步研究 这项建议的目标如下：1） 揭示了毒蕈碱胆碱能受体（M1和M2）的亚型， 大脑受到低水平微波的影响; 2）研究 内源性阿片受体（即，mu、delta和kappa）和 在大脑中，它们介导了微波引起的胆碱能变化， 活性;并研究阿片受体在 3）在重复微波暴露后的大脑中确定位置， CRF介导微波引起的中枢神经系统变化的大脑 胆碱能活性 此外，由于申请人还发现， 低强度微波辐射影响空间学习和记忆 功能，提出了进一步的实验来研究神经机制 参与了学习缺陷。

The applicants propose experiments to further investigate the neural mechanisms involved in the neurological effects of low-level microwave irradiation in the rat. In previous research, the applicants found that acute low-level microwave exposure changed the activity of the cholinergic systems in the rat brain, and after repeated exposure, changes occurred in the muscarinic cholinergic receptors. Furthermore, the applicants found that the effects were mediated by endogenous opioids and corticotropin- releasing factor (CRF) in the brain. To further study the neural mechanisms involved, this proposal has the following objectives: 1) to reveal the subtypes of muscarinic cholinergic receptors (M1 and M2) in the brain affected by low-level microwaves; 2) to investigate the subtypes of endogenous opioid receptors (i.e., mu, delta, and kappa) and the loci in the brain where they mediate the microwave-induced changes in cholinergic activity; and to study the possible changes in opioid receptors in the brain after repeated microwave exposure and 3) to determine the location in the brain where CRF mediates the microwave-induced changes in central cholinergic activity. In addition, since the applicant has also found that low-level microwave irradiation affects spatial learning and memory functions, further experiments are proposed to study the neural mechanisms involved in the learning deficient.