NEURAL EFFECTS OF LOW-LEVEL MICROWAVES

我们建议进行实验来继续研究 低强度微波辐射对神经功能的影响 老鼠。 在之前的研究中，我们发现急性暴露于低 微波水平影响钠依赖性高亲和力胆碱 摄取，神经组织中胆碱能活性的衡量标准， 大鼠大脑的各个区域。 由于胆碱能系统 大脑具有重要的功能，我们将利用这种效应作为 因变量来研究（不同的交互作用 辐照参数：功率密度、持续时间、脉冲与 连续波照射，圆偏振与平面偏振 波浪。 微波引起的变化的功能后果 将通过研究来调查大脑中的胆碱能活动 径向臂迷宫表现，短期空间测量 记忆。 通过治疗可能逆转学习缺陷 将研究麻醉拮抗剂的作用。 长期变化 将研究重复暴露后的神经功能 通过测量毒蕈碱胆碱能受体特性 大脑的不同区域。 其他人的参与 微波对中枢神经递质的影响 将通过治疗动物来研究胆碱能活性 暴露前的各种递质拮抗剂。 我们的研究数据还表明，一些神经系统疾病 低强度微波暴露的影响是由内源性介导的 阿片类药物。 我们提出了一系列实验来测量水平 三种内源性阿片类药物：β-内啡肽、met- 脑啡肽和亮氨酸脑啡肽位于大脑的不同区域 急性或反复暴露于微波后。 希望这项研究的结果能够进一步 我们对介导的神经化学机制的理解 低强度微波辐射的神经系统效应 这些影响的行为后果。

We propose experiments to continue our studies on the effects of low-level microwave irradiation on neurological functions in the rat. In previous research, we found that acute exposure to low- level microwaves affected sodium-dependent high-affinity choline uptake, a measure of cholinergic activity in neural tissue, in various regions of the rat brain. Since cholinergic systems in the brain serve important functions, we will use this effect as the dependent variable to study the (interaction effects of different parameters of irradiation: power density, duration, pulsed versus continuous-wave irradiation, and circularly versus plane-polarized waves. Functional consequence of microwave-induced changes in cholinergic activity in the brain will be investigated by studying radial-arm maze performance, a measure of short-term spatial memory. Possible reversal of the learning deficit by treatment with narcotic antagonists will be investigated. Long-term changes in neural functions after repeated exposure will be investigated by measurements of muscarinic cholinergic receptor properties in different regions of the brain. Involvements of other neurotransmitters in the effects of microwaves on central cholinergic activity will be studied by treating animals with various transmitter antagonists before exposure. Data from our research also indicate that some of the neurological effects of low-level microwave exposure are mediated by endogenous opioids. We propose a series of experiments to measure the levels of three types of endogenous opioids: beta-endorphin, met- enkephalin, and leu-enkephalin, in different regions of the brain after acute or repeated exposure to microwaves. It is hoped that results from this proposed research will further our understanding of the neurochemical mechanism mediating the neurological effects of low-level microwave irradiation and the behavioral consequence of these effects.