Modeling the cost of a process for the manufacture of succinic acid by fermentation of syngas

该项目将开发BioSyntha的新技术的过程经济学模型，用于通过发酵木质纤维素生物质制成的合成气合成平台化学品。该模式将支持Biosyntha的商业计划，以最大限度地提高其研发价值。合成气发酵在世界上处于起步阶段，并且没有现成的合成气发酵过程模型。该项目将通过调整工艺参数，如目标产品产量和生产率，与代谢工程目标相一致，协助将该技术开发为完全商业化生产。通过发酵方法将来自多种灵活来源的合成气转化为平台化学品的原理的经济验证，以及与替代路线的比较，将使公司能够吸引更多投资并与工业合作伙伴建立合作关系。

This project will develop a model of the process economics of BioSyntha's novel technology for synthesis of platform chemicals by fermentation of syngas made from lignocellulosic biomass. The model will underpin Biosyntha's business plan to maximise and extract value from its R&D. Syngas fermentation is in its infancy in the world and there is no readily available model for syngas fermentation processes. This project will assist in the development of this technology into full commercial production by aligning process parameters such as target product yields and production rates, with metabolic engineering objectives. Economic validation of the principle of converting syngas derived from multiple and flexible sources to platform chemicals by a fermentative approach, and comparison with alternate routes, will allow the company to attract further investment and to develop collaborative relationships with industrial partners.